HCSGD entry for ANKRD1

1. General information

Official gene symbolANKRD1
Entrez ID27063
Gene full nameankyrin repeat domain 1 (cardiac muscle)
Other gene symbolsALRP C-193 CARP CVARP MCARP bA320F15.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0002039P53 bindingIPImolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0031432Titin bindingIPImolecular_function
GO:0031674I bandISScellular_component
GO:0035690Cellular response to drugIEAbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0035994Response to muscle stretchIMPbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorIDAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045214Sarcomere organizationNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050714Positive regulation of protein secretionIMPbiological_process
GO:0055008Cardiac muscle tissue morphogenesisIMPbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0071260Cellular response to mechanical stimulusIDAbiological_process
GO:0071347Cellular response to interleukin-1IDAbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:2000279Negative regulation of DNA biosynthetic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00443587630.03113686030.17731742420.3313753331

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9775228121
GSE13712_SHEARUp1.4585559800
GSE13712_STATICUp0.4367655608
GSE19018Down-0.6905477680
GSE19899_A1Down-0.1645889489
GSE19899_A2Up0.6683063120
PubMed_21979375_A1Up0.5164145371
PubMed_21979375_A2Down-0.2133250306
GSE35957Down-0.1265344341
GSE36640Up3.5166239650
GSE54402Up0.1705668883
GSE9593Down-0.1451189269
GSE43922Up0.0019236199
GSE24585Down-0.4931508409
GSE37065Up0.2032086193
GSE28863_A1Down-1.3065723194
GSE28863_A2Up0.0265364369
GSE28863_A3Up0.8924690324
GSE28863_A4Up0.5876042291
GSE48662Up1.1775978401

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019931MicroarrayFunctional MTI (Weak)20215506
hsa-miR-181a-5pMIMAT0000256MIRT025157MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.