HCSGD entry for GJB2
1. General information
| Official gene symbol | GJB2 |
|---|---|
| Entrez ID | 2706 |
| Gene full name | gap junction protein, beta 2, 26kDa |
| Other gene symbols | CX26 DFNA3 DFNA3A DFNB1 DFNB1A HID KID NSRD1 PPK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005243 | Gap junction channel activity | IEA | molecular_function |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005922 | Connexon complex | IEA | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | IEA | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016264 | Gap junction assembly | TAS | biological_process |
| GO:0016328 | Lateral plasma membrane | IEA | cellular_component |
| GO:0030539 | Male genitalia development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0007694009 | 0.7055776566 | 0.0775915709 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2536328270 |
| GSE13712_SHEAR | Up | 0.1160560247 |
| GSE13712_STATIC | Down | -0.1550956018 |
| GSE19018 | Down | -0.3346826306 |
| GSE19899_A1 | Up | 2.1132401098 |
| GSE19899_A2 | Up | 6.3265257254 |
| PubMed_21979375_A1 | Up | 7.0970777611 |
| PubMed_21979375_A2 | Up | 6.1479691659 |
| GSE35957 | Down | -0.2949702330 |
| GSE36640 | Down | -1.8897162398 |
| GSE54402 | Up | 1.8405520768 |
| GSE9593 | Down | -0.0987470319 |
| GSE43922 | Up | 0.6876418762 |
| GSE24585 | Down | -0.0485604209 |
| GSE37065 | Up | 0.4668550552 |
| GSE28863_A1 | Up | 0.0469864803 |
| GSE28863_A2 | Down | -0.1720457799 |
| GSE28863_A3 | Up | 0.1536792081 |
| GSE28863_A4 | Up | 0.1781967579 |
| GSE48662 | Down | -0.1576793943 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016358 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017821 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
