HCSGD entry for NPHP3

1. General information

Official gene symbolNPHP3
Entrez ID27031
Gene full namenephronophthisis 3 (adolescent)
Other gene symbolsMKS7 NPH3 RHPD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIMPbiological_process
GO:0001947Heart loopingIMPbiological_process
GO:0003283Atrial septum developmentIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005929CiliumIDAcellular_component
GO:0006629Lipid metabolic processIEAbiological_process
GO:0007163Establishment or maintenance of cell polarityIEAbiological_process
GO:0007368Determination of left/right symmetryIMPbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030324Lung developmentIMPbiological_process
GO:0030814Regulation of cAMP metabolic processIEAbiological_process
GO:0035469Determination of pancreatic left/right asymmetryIMPbiological_process
GO:0045494Photoreceptor cell maintenanceIMPbiological_process
GO:0048496Maintenance of organ identityIMPbiological_process
GO:0060027Convergent extension involved in gastrulationIGIbiological_process
GO:0060271Cilium morphogenesisISSbiological_process
GO:0060287Epithelial cilium movement involved in determination of left/right asymmetryICbiological_process
GO:0060993Kidney morphogenesisIMPbiological_process
GO:0071908Determination of intestine left/right asymmetryIMPbiological_process
GO:0071909Determination of stomach left/right asymmetryIMPbiological_process
GO:0071910Determination of liver left/right asymmetryIMPbiological_process
GO:0072189Ureter developmentIMPbiological_process
GO:0072372Primary ciliumIDAcellular_component
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:2000095Regulation of Wnt signaling pathway, planar cell polarity pathwayISSbiological_process
GO:2000167Regulation of planar cell polarity pathway involved in neural tube closureICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61039272060.39585228520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2373385505
GSE13712_SHEARUp0.2939397987
GSE13712_STATICUp0.1192795318
GSE19018Up0.2992427584
GSE19899_A1Down-0.1952289149
GSE19899_A2Up0.1318874480
PubMed_21979375_A1Down-0.0089111062
PubMed_21979375_A2Down-0.1098039915
GSE35957Down-0.0257508702
GSE36640Up0.1321570959
GSE54402Down-0.0736506514
GSE9593Up0.0862762767
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.1063686836
GSE28863_A2Up0.2032117838
GSE28863_A3Down-0.7856739682
GSE28863_A4Down-0.2740859265
GSE48662Up0.3177238618

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024459MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026854MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.