HCSGD entry for GJA5

1. General information

Official gene symbolGJA5
Entrez ID2702
Gene full namegap junction protein, alpha 5, 40kDa
Other gene symbolsATFB11 CX40
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0001525AngiogenesisIEPbiological_process
GO:0003105Negative regulation of glomerular filtrationIEAbiological_process
GO:0003151Outflow tract morphogenesisIMPbiological_process
GO:0003158Endothelium developmentIEAbiological_process
GO:0003161Cardiac conduction system developmentIEAbiological_process
GO:0003174Mitral valve developmentIMPbiological_process
GO:0003193Pulmonary valve formationIMPbiological_process
GO:0003281Ventricular septum developmentIMPbiological_process
GO:0003283Atrial septum developmentIMPbiological_process
GO:0003284Septum primum developmentIEAbiological_process
GO:0003294Atrial ventricular junction remodelingIEAbiological_process
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005921Gap junctionIDAcellular_component
GO:0005922Connexon complexIDAcellular_component
GO:0006813Potassium ion transportIEAbiological_process
GO:0010643Cell communication by chemical couplingIEAbiological_process
GO:0010652Positive regulation of cell communication by chemical couplingIEAbiological_process
GO:0014704Intercalated discIDA TAScellular_component
GO:0016264Gap junction assemblyIDA IMPbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0035050Embryonic heart tube developmentIEAbiological_process
GO:0035922Foramen ovale closureIEAbiological_process
GO:0042995Cell projectionIEAcellular_component
GO:0045776Negative regulation of blood pressureIEAbiological_process
GO:0045907Positive regulation of vasoconstrictionIEAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0048844Artery morphogenesisISSbiological_process
GO:0051259Protein oligomerizationIEAbiological_process
GO:0055077Gap junction hemi-channel activityIDAmolecular_function
GO:0055085Transmembrane transportIDA IMPbiological_process
GO:0055117Regulation of cardiac muscle contractionIMPbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIEAbiological_process
GO:0060371Regulation of atrial cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0060373Regulation of ventricular cardiac muscle cell membrane depolarizationIEAbiological_process
GO:0060412Ventricular septum morphogenesisIEAbiological_process
GO:0060413Atrial septum morphogenesisIEAbiological_process
GO:0071253Connexin bindingIEAmolecular_function
GO:0086005Ventricular cardiac muscle cell action potentialIEAbiological_process
GO:0086014Atrial cardiac muscle cell action potentialIMPbiological_process
GO:0086015SA node cell action potentialIEAbiological_process
GO:0086053AV node cell to bundle of His cell communication by electrical couplingIMPbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionIDAbiological_process
GO:0086069Bundle of His cell to Purkinje myocyte communicationIMPbiological_process
GO:0086075Gap junction channel activity involved in cardiac conduction electrical couplingIDA IMPmolecular_function
GO:0086077Gap junction channel activity involved in AV node cell-bundle of His cell electrical couplingIDAmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIEAbiological_process
GO:1900133Regulation of renin secretion into blood streamIEAbiological_process
GO:1900825Regulation of membrane depolarization during cardiac muscle cell action potentialIEAbiological_process
GO:1990029VasomotionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69986302570.84091661410.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0163557911
GSE13712_SHEARUp0.0665151773
GSE13712_STATICUp0.0646048627
GSE19018Up0.1299082800
GSE19899_A1Up0.0431601271
GSE19899_A2Up0.0175624793
PubMed_21979375_A1Down-0.2047810933
PubMed_21979375_A2Up0.0030399443
GSE35957Up0.1369265467
GSE36640Up0.2706391240
GSE54402Up0.0533982588
GSE9593Up0.0135138919
GSE43922Up0.0147879319
GSE24585Up0.2995635082
GSE37065Down-0.1348088620
GSE28863_A1Down-0.2240448500
GSE28863_A2Down-0.0151076508
GSE28863_A3Up0.0826398815
GSE28863_A4Down-0.0500327250
GSE48662Up0.0991971822

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028999MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.