HCSGD entry for NGFRAP1
1. General information
| Official gene symbol | NGFRAP1 |
|---|---|
| Entrez ID | 27018 |
| Gene full name | nerve growth factor receptor (TNFRSF16) associated protein 1 |
| Other gene symbols | BEX3 Bex DXS6984E HGR74 NADE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005123 | Death receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008625 | Extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | TAS | molecular_function |
| GO:0010952 | Positive regulation of peptidase activity | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043281 | Regulation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8675723567 | 0.1819286843 | 0.9999902473 | 0.8270378215 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2118739976 |
| GSE13712_SHEAR | Down | -0.0928901737 |
| GSE13712_STATIC | Down | -0.0878044887 |
| GSE19018 | Up | 0.0866980484 |
| GSE19899_A1 | Down | -0.2034064694 |
| GSE19899_A2 | Down | -0.1558888298 |
| PubMed_21979375_A1 | Down | -0.6239039349 |
| PubMed_21979375_A2 | Down | -0.2807057465 |
| GSE35957 | Down | -0.0399192308 |
| GSE36640 | Up | 0.2479420593 |
| GSE54402 | Down | -0.0167457832 |
| GSE9593 | Up | 0.0098397881 |
| GSE43922 | Down | -0.3871808170 |
| GSE24585 | Down | -0.2410666804 |
| GSE37065 | Up | 0.2634905263 |
| GSE28863_A1 | Down | -0.0821064709 |
| GSE28863_A2 | Down | -0.0539639781 |
| GSE28863_A3 | Down | -0.2907079584 |
| GSE28863_A4 | Up | 0.3815237118 |
| GSE48662 | Down | -0.1867704692 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT037110 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051160 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
