HCSGD entry for TPK1

1. General information

Official gene symbolTPK1
Entrez ID27010
Gene full namethiamin pyrophosphokinase 1
Other gene symbolsHTPK1 PP20 THMD5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004788Thiamine diphosphokinase activityIEA TASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0006772Thiamine metabolic processIEAbiological_process
GO:0009229Thiamine diphosphate biosynthetic processIEAbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0042723Thiamine-containing compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00490326360.99228392160.18365582391.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3961612597
GSE13712_SHEARUp1.1168932667
GSE13712_STATICUp1.7777292147
GSE19018Down-0.1788437146
GSE19899_A1Up0.2465203427
GSE19899_A2Up1.0165211383
PubMed_21979375_A1Up0.7744174252
PubMed_21979375_A2Up1.4148529760
GSE35957Up0.4370706192
GSE36640Up0.0534180840
GSE54402Up0.3562545206
GSE9593Up0.0160334117
GSE43922Up0.0208866854
GSE24585Up0.3872711424
GSE37065Up0.4671455926
GSE28863_A1Down-0.0596103612
GSE28863_A2Up0.0961743826
GSE28863_A3Up0.1393414541
GSE28863_A4Up0.0569316669
GSE48662Down-0.0683163876

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ThiamineDB00152 NUTR00009 | APRD00552 | EXPT03222
Pyrithiamine PyrophosphateDB04768 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.