HCSGD entry for USP21
1. General information
| Official gene symbol | USP21 |
|---|---|
| Entrez ID | 27005 |
| Gene full name | ubiquitin specific peptidase 21 |
| Other gene symbols | USP16 USP23 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003713 | Transcription coactivator activity | ISS | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA ISS TAS | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IMP ISS | molecular_function |
| GO:0016578 | Histone deubiquitination | ISS | biological_process |
| GO:0019784 | NEDD8-specific protease activity | IDA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9712121272 | 0.0484535998 | 0.9999902473 | 0.4119569906 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0495073458 |
| GSE13712_SHEAR | Down | -0.6175783398 |
| GSE13712_STATIC | Down | -0.5539996426 |
| GSE19018 | Up | 0.0864209844 |
| GSE19899_A1 | Down | -0.1938446529 |
| GSE19899_A2 | Down | -0.3887999481 |
| PubMed_21979375_A1 | Down | -0.1879028329 |
| PubMed_21979375_A2 | Up | 0.1580720960 |
| GSE35957 | Down | -1.0603591556 |
| GSE36640 | Down | -0.4816159808 |
| GSE54402 | Up | 0.0907606644 |
| GSE9593 | Down | -0.4595104563 |
| GSE43922 | Down | -0.0204934926 |
| GSE24585 | Up | 0.0598950130 |
| GSE37065 | Down | -0.0657331351 |
| GSE28863_A1 | Up | 0.1980680806 |
| GSE28863_A2 | Up | 0.1201449095 |
| GSE28863_A3 | Down | -0.1304384934 |
| GSE28863_A4 | Down | -0.2614963198 |
| GSE48662 | Up | 0.0241119044 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT028020 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028308 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037440 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039291 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043379 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
