HCSGD entry for PABPC1
1. General information
| Official gene symbol | PABPC1 |
|---|---|
| Entrez ID | 26986 |
| Gene full name | poly(A) binding protein, cytoplasmic 1 |
| Other gene symbols | PAB1 PABP PABP1 PABPC2 PABPL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003729 | MRNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006378 | MRNA polyadenylation | TAS | biological_process |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006417 | Regulation of translation | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008143 | Poly(A) binding | IDA TAS | molecular_function |
| GO:0008266 | Poly(U) RNA binding | IDA | molecular_function |
| GO:0008494 | Translation activator activity | TAS | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IDA | cellular_component |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0031047 | Gene silencing by RNA | IEA ISS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045727 | Positive regulation of translation | TAS | biological_process |
| GO:0048255 | MRNA stabilization | TAS | biological_process |
| GO:0060213 | Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | IEA ISS | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
| GO:1900153 | Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IEA ISS | biological_process |
| GO:2000623 | Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8504497018 | 0.4706450971 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1861875612 |
| GSE13712_SHEAR | Down | -0.0848618189 |
| GSE13712_STATIC | Down | -0.0549841021 |
| GSE19018 | Up | 0.1182742634 |
| GSE19899_A1 | Down | -0.0899933388 |
| GSE19899_A2 | Up | 0.0023527351 |
| PubMed_21979375_A1 | Down | -0.0943930399 |
| PubMed_21979375_A2 | Up | 0.1594535848 |
| GSE35957 | Up | 0.1267692613 |
| GSE36640 | Down | -0.2715908792 |
| GSE54402 | Up | 0.2402828693 |
| GSE9593 | Up | 0.1667422977 |
| GSE43922 | Down | -0.1779341748 |
| GSE24585 | Down | -0.1938074592 |
| GSE37065 | Down | -0.5081651759 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1194608256 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004993 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028502 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1295a | MIMAT0005885 | MIRT035902 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037728 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038147 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040841 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041210 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042479 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045519 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047328 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047501 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047745 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052261 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20943973 | NFX1-123, the longer splice variant of NFX1, interacts with HPV16 E6, as well as cytoplasmic poly(A) binding proteins 1 and 4 (PABPC1 and PABPC4) |
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