HCSGD entry for HBP1
1. General information
| Official gene symbol | HBP1 |
|---|---|
| Entrez ID | 26959 |
| Gene full name | HMG-box transcription factor 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | NAS | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0043268 | Positive regulation of potassium ion transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0285527564 | 0.7487372858 | 0.3927398230 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1364797074 |
| GSE13712_SHEAR | Up | 0.2719106031 |
| GSE13712_STATIC | Up | 0.1849348650 |
| GSE19018 | Up | 0.5112246605 |
| GSE19899_A1 | Up | 0.2029757498 |
| GSE19899_A2 | Down | -0.1424606590 |
| PubMed_21979375_A1 | Up | 0.0084070643 |
| PubMed_21979375_A2 | Up | 0.1038119050 |
| GSE35957 | Up | 0.4214682170 |
| GSE36640 | Up | 0.7804901412 |
| GSE54402 | Up | 0.1210886325 |
| GSE9593 | Up | 0.2644340970 |
| GSE43922 | Up | 0.0107464864 |
| GSE24585 | Up | 1.4874493251 |
| GSE37065 | Up | 0.2580341908 |
| GSE28863_A1 | Up | 0.1185514023 |
| GSE28863_A2 | Up | 0.2561124938 |
| GSE28863_A3 | Down | -0.6213440166 |
| GSE28863_A4 | Down | -0.5286415815 |
| GSE48662 | Down | -0.1176006473 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018624 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020927 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031302 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT031371 | Reporter assay | Functional MTI | 20505989 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT035539 | Luciferase reporter assay | Functional MTI | 23541945 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050750 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27129219 | In this study, we demonstrate that the high-mobility group box-containing protein 1 (HBP1) transcription factor is a novel activator of p21 that works as part of a complex mechanism during senescence and tumorigenesis |
| 27129219 | We found that HBP1 activates the p21 gene through enhancing p53 stability by inhibiting Mdm2-mediated ubiquitination of p53, a well known positive regulator of p21 |
| 27129219 | HBP1 was also found to enhance p21 transcription by inhibiting Wnt/beta-catenin signaling |
| 27129219 | Although intricate, the reciprocal partnership of HBP1 and p21 has exceptional importance |
| 27129219 | Together, our results suggest that the HBP1 transcription factor orchestrates a complex regulation of key genes during cellular senescence and tumorigenesis with an impact on protein ubiquitination and overall histone methylation state |
| 26718972 | Interestingly, knockdown of HMG box-containing protein 1 (HBP1) partially blocked the cellular senescence of AMPKalpha2-deleted MEFs via the reduction of p16 |
| 26718972 | Finally, dermal cells senescence, including fibroblasts senescence evidenced by the staining of p16, HBP1, and Ki-67, in the skin of aged AMPKalpha2(-/-) mice was enhanced when compared with that in wild type mice |
| 23859194 | Furthermore, HMG box transcription factor 1 (HBP1), a downstream target of the mitogen-activated protein kinase p38-mediated senescence pathway, was required for SAHF formation |
| 23249948 | In this study, we demonstrated that the HMG box-containing protein 1 (HBP1) transcription factor is a new repressor of DNMT1 in a complex mechanism during senescence |
| 23249948 | HBP1 repressed the endogenous DNMT1 gene through sequence-specific binding, resulting in both gene-specific (e |
| 23249948 | The HBP1-mediated repression by DNMT1 contributed to replicative and premature senescence, the latter of which could be induced by Ras and HBP1 itself |
| 23249948 | A detailed investigation unexpectedly revealed that HBP1 has dual and complex transcriptional functions, both of which contribute to premature senescence |
| 23249948 | HBP1 both repressed the DNMT1 gene and activated the p16 gene in premature senescence |
| 23249948 | While intricate, the reciprocal partnership between HBP1 and DNMT1 has exceptional importance, since its abrogation compromises senescence and promotes tumorigenesis |
| 23249948 | Together, our results suggest that the HBP1 transcription factor orchestrates a complex regulation of key genes during cellular senescence, with an impact on overall DNA methylation state |
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