HCSGD entry for GFRA1
1. General information
| Official gene symbol | GFRA1 |
|---|---|
| Entrez ID | 2674 |
| Gene full name | GDNF family receptor alpha 1 |
| Other gene symbols | GDNFR GDNFRA GFR-ALPHA-1 RET1L RETL1 TRNR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007166 | Cell surface receptor signaling pathway | NAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0016167 | Glial cell-derived neurotrophic factor receptor activity | TAS | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019898 | Extrinsic component of membrane | TAS | cellular_component |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0035860 | Glial cell-derived neurotrophic factor receptor signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1057703545 | 0.0172467535 | 0.6750682590 | 0.2574145845 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0103617311 |
| GSE13712_SHEAR | Down | -0.0444584282 |
| GSE13712_STATIC | Up | 0.0342771143 |
| GSE19018 | Down | -1.0665399356 |
| GSE19899_A1 | Down | -0.0892167216 |
| GSE19899_A2 | Down | -0.7136221649 |
| PubMed_21979375_A1 | Down | -1.2183727632 |
| PubMed_21979375_A2 | Down | -0.4742975010 |
| GSE35957 | Up | 0.9040935730 |
| GSE36640 | Up | 1.0624524423 |
| GSE54402 | Down | -3.8869524705 |
| GSE9593 | Up | 1.0438727747 |
| GSE43922 | Down | -0.8945959059 |
| GSE24585 | Up | 0.4862728502 |
| GSE37065 | Up | 0.5745568872 |
| GSE28863_A1 | Up | 0.5267199831 |
| GSE28863_A2 | Up | 0.3134518047 |
| GSE28863_A3 | Down | -0.3300028698 |
| GSE28863_A4 | Up | 0.0182740353 |
| GSE48662 | Up | 0.1554456759 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019251 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025678 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
