HCSGD entry for GFAP

1. General information

Official gene symbolGFAP
Entrez ID2670
Gene full nameglial fibrillary acidic protein
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005178Integrin bindingIEAmolecular_function
GO:0005198Structural molecule activityIEAmolecular_function
GO:0005200Structural constituent of cytoskeletonIEAmolecular_function
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005882Intermediate filamentIEAcellular_component
GO:0009611Response to woundingIEAbiological_process
GO:0010625Positive regulation of Schwann cell proliferationIEAbiological_process
GO:0010977Negative regulation of neuron projection developmentIEAbiological_process
GO:0014002Astrocyte developmentIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019900Kinase bindingIEAmolecular_function
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0031102Neuron projection regenerationIEAbiological_process
GO:0044297Cell bodyIEAcellular_component
GO:0045109Intermediate filament organizationIEAbiological_process
GO:0051580Regulation of neurotransmitter uptakeIEAbiological_process
GO:0060020Bergmann glial cell differentiationIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0097449Astrocyte projectionIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75279746590.80310242010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0630479330
GSE13712_SHEARUp0.0613420583
GSE13712_STATICDown-0.1016355379
GSE19018Up0.0089753316
GSE19899_A1Up0.0011587961
GSE19899_A2Up0.0070930963
PubMed_21979375_A1Up0.0703267930
PubMed_21979375_A2Up0.0871800158
GSE35957Up0.0531491356
GSE36640Down-0.0237332852
GSE54402Up0.0226330317
GSE9593Down-0.0197164371
GSE43922Up0.0761438498
GSE24585Down-0.0143759553
GSE37065Down-0.0914186090
GSE28863_A1Up0.0030817881
GSE28863_A2Down-0.0299346278
GSE28863_A3Up0.1913961832
GSE28863_A4Up0.1661029316
GSE48662Down-0.0131184563

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016984MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27630559Remarkably, several genes indicative of astrocytic responses to injury were also downregulated, including glial fibrillary acidic protein and genes involved in the processing and presentation of antigens by major histocompatibility complex class II proteins, while pro-inflammatory genes were upregulated
25553648In addition, aged Nfkb1-/- animals have increased kyphosis, decreased cortical bone, increased brain GFAP staining and a decrease in overall lifespan compared to Nfkb1+/+
25411512Glial fibrillary acidic protein, a control for immunoreactivity, was positive in 46 cases (96%)
24464841Using approaches that include a novel method to measure tumorsphere sizes and the area covered by spheres in GBM cultures, as well as a nuclear morphometric analysis, we show that TSA reduced proliferation and colony sizes, led to G2/M arrest, induced alterations in nuclear morphology consistent with cell senescence, and increased the protein content of GFAP, but did not affect migration, in cultured human U87 GBM cells
24293183Moreover, there was no indication that the amount of glial fibrillary acidic protein or the number of apoptotic cells in the brain was altered significantly over the course of adult life
24052948We demonstrate that BMP2 is necessary to induce expression of the astrocyte marker GFAP in irradiated NSCs via a noncanonical signaling pathway engaging JAK-STAT
21649759Astrocytes demonstrate age-related changes that resemble those of the SASP: (i) increased level of intermediate glial fibrillary acidic protein and vimentin filaments, (ii) increased expression of several cytokines and (iii) increased accumulation of proteotoxic aggregates
15958744At both stages, colocalization of bromodeoxyuridine and GFAP demonstrated that Bmi1 loss did not prevent astrocyte precursor proliferation
1917778The results of immunoblotting showed that the expression of vimentin was much higher than that of GFAP
2359142In cultures initiated from the neopallium of newborn mice, the glial fibrillary acidic protein (GFAP)+ stellate astrocytes were statin-negative (statin-) but cyclin-positive (cyclin+)
2359142In frozen sections of the brains of adult mice and in brain smears, GFAP+ astrocytes were statin-
2154283To evaluate the cellular differentiation, cell morphology and the number of glial fibrillary acidic protein (GFAP) positive cells were examined
2870196Glial cell cultures derived from newborn and aged (18-month-old) mouse cerebral hemispheres and maintained up to cell passage 11 were characterized immunocytochemically by using glial fibrillary acidic protein (GFA), and biochemically by using glutamine synthetase (GS), for astrocytes, and 2',3' cyclic nucleotide 3' phosphohydrolase (CNP) for oligodendrocytes
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