HCSGD entry for GDNF

1. General information

Official gene symbolGDNF
Entrez ID2668
Gene full nameglial cell derived neurotrophic factor
Other gene symbolsATF1 ATF2 HFB1-GDNF HSCR3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001656Metanephros developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisISSbiological_process
GO:0001755Neural crest cell migrationIDAbiological_process
GO:0001759Organ inductionIEAbiological_process
GO:0001941Postsynaptic membrane organizationIEAbiological_process
GO:0003337Mesenchymal to epithelial transition involved in metanephros morphogenesisIEAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008344Adult locomotory behaviorTASbiological_process
GO:0021784Postganglionic parasympathetic nervous system developmentISSbiological_process
GO:0030432PeristalsisISSbiological_process
GO:0031175Neuron projection developmentIDAbiological_process
GO:0032770Positive regulation of monooxygenase activityIDAbiological_process
GO:0033603Positive regulation of dopamine secretionTASbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043524Negative regulation of neuron apoptotic processIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048255MRNA stabilizationIDAbiological_process
GO:0048484Enteric nervous system developmentISSbiological_process
GO:0048485Sympathetic nervous system developmentISSbiological_process
GO:0051584Regulation of dopamine uptake involved in synaptic transmissionIDAbiological_process
GO:0060676Ureteric bud formationIEAbiological_process
GO:0060688Regulation of morphogenesis of a branching structureISSbiological_process
GO:0072107Positive regulation of ureteric bud formationIDAbiological_process
GO:0072108Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisIEAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIDAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00460301660.97548017930.17852385861.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0354618562
GSE13712_SHEARDown-0.0224081588
GSE13712_STATICDown-0.0298568061
GSE19018Up0.0407390427
GSE19899_A1Up0.5870677726
GSE19899_A2Up1.3772862411
PubMed_21979375_A1Up1.2528442905
PubMed_21979375_A2Up1.0078715267
GSE35957Up0.1436505213
GSE36640Up0.3514234745
GSE54402Up1.8943507333
GSE9593Down-0.0044050737
GSE43922Up0.5747113953
GSE24585Up0.2922896483
GSE37065Up0.0478973775
GSE28863_A1Down-0.3835092481
GSE28863_A2Up0.6551527396
GSE28863_A3Up0.5129921504
GSE28863_A4Down-0.1727594718
GSE48662Up0.2229292994

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AV411DB05066 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019438MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT022032MicroarrayFunctional MTI (Weak)17612493
hsa-miR-7-5pMIMAT0000252MIRT025911MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25443290This can be partially reversed by glial cell line-derived neurotrophic factor (GDNF)
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