HCSGD entry for IL36RN
1. General information
| Official gene symbol | IL36RN |
|---|---|
| Entrez ID | 26525 |
| Gene full name | interleukin 36 receptor antagonist |
| Other gene symbols | FIL1 FIL1(DELTA) FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 IL36RA PSORP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001960 | Negative regulation of cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005149 | Interleukin-1 receptor binding | IEA | molecular_function |
| GO:0005152 | Interleukin-1 receptor antagonist activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0010469 | Regulation of receptor activity | TAS | biological_process |
| GO:0032715 | Negative regulation of interleukin-6 production | IEA | biological_process |
| GO:1900116 | Extracellular negative regulation of signal transduction | TAS | biological_process |
| GO:2000272 | Negative regulation of receptor activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0014161886 | 0.9919026709 | 0.1010823848 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1420732861 |
| GSE13712_SHEAR | Up | 0.2438141171 |
| GSE13712_STATIC | Up | 0.2931249967 |
| GSE19018 | Up | 0.2091894362 |
| GSE19899_A1 | Up | 0.2296084254 |
| GSE19899_A2 | Up | 2.2156254111 |
| PubMed_21979375_A1 | Up | 6.8984824587 |
| PubMed_21979375_A2 | Up | 1.3589343618 |
| GSE35957 | Up | 0.1245319576 |
| GSE36640 | Down | -0.1256986662 |
| GSE54402 | Up | 4.6164366220 |
| GSE9593 | Up | 0.2428548675 |
| GSE43922 | Up | 0.2763643732 |
| GSE24585 | Down | -0.0227934862 |
| GSE37065 | Up | 0.2972505160 |
| GSE28863_A1 | Down | -0.0759517577 |
| GSE28863_A2 | Up | 0.1561384174 |
| GSE28863_A3 | Up | 0.1698140071 |
| GSE28863_A4 | Up | 0.1752294019 |
| GSE48662 | Up | 0.0210939070 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018357 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029800 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051062 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
