HCSGD entry for LATS2
1. General information
| Official gene symbol | LATS2 |
|---|---|
| Entrez ID | 26524 |
| Gene full name | large tumor suppressor kinase 2 |
| Other gene symbols | KPM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0004674 | Protein serine/threonine kinase activity | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0009755 | Hormone-mediated signaling pathway | IDA | biological_process |
| GO:0030216 | Keratinocyte differentiation | IEA | biological_process |
| GO:0034613 | Cellular protein localization | IEA | biological_process |
| GO:0035329 | Hippo signaling | IDA TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0045736 | Negative regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | biological_process |
| GO:0046620 | Regulation of organ growth | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4254050720 | 0.1198016527 | 0.9999902473 | 0.6651126977 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4905617478 |
| GSE13712_SHEAR | Up | 0.5153469024 |
| GSE13712_STATIC | Up | 0.2861312512 |
| GSE19018 | Up | 0.4931385858 |
| GSE19899_A1 | Down | -0.6485923549 |
| GSE19899_A2 | Down | -0.0113421910 |
| PubMed_21979375_A1 | Down | -0.0134940602 |
| PubMed_21979375_A2 | Down | -0.1558581439 |
| GSE35957 | Up | 0.5085149203 |
| GSE36640 | Up | 0.3620917945 |
| GSE54402 | Down | -0.6959570594 |
| GSE9593 | Up | 0.4450603426 |
| GSE43922 | Down | -0.6489937789 |
| GSE24585 | Up | 0.1386795526 |
| GSE37065 | Down | -0.2212380547 |
| GSE28863_A1 | Up | 0.1081670822 |
| GSE28863_A2 | Down | -0.0840340630 |
| GSE28863_A3 | Down | -0.0887902081 |
| GSE28863_A4 | Down | -0.1286210812 |
| GSE48662 | Down | -0.3489558649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT000491 | qRT-PCR//Luciferase reporter assay | Functional MTI | 20237410 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT001754 | Luciferase reporter assay//Western blot | Functional MTI | 19501585 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT001754 | Luciferase reporter assay//Western blot | Functional MTI | 20216554 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT001754 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay | Functional MTI | 16564011 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT001754 | Luciferase reporter assay//Western blot | Functional MTI | 22027184 |
| hsa-miR-372-3p | MIMAT0000724 | MIRT002446 | Luciferase reporter assay | Functional MTI | 18155131 |
| hsa-miR-372-3p | MIMAT0000724 | MIRT002446 | Luciferase reporter assay//Western blot | Functional MTI | 20216554 |
| hsa-miR-372-3p | MIMAT0000724 | MIRT002446 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay | Functional MTI | 16564011 |
| hsa-miR-372-3p | MIMAT0000724 | MIRT002446 | Luciferase reporter assay//Western blot | Functional MTI | 22027184 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT007185 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23111389 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{mutation} | 16564011 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27358050 | Here we report that the Hippo pathway controls liver cell lineage specification and proliferation separately from Notch signalling, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the direct upstream regulators of YAP and TAZ |
| 22068052 | We show here that the ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability of p53 to induce p21, cell-cycle arrest and senescence |
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