HCSGD entry for GCH1
1. General information
| Official gene symbol | GCH1 |
|---|---|
| Entrez ID | 2643 |
| Gene full name | GTP cyclohydrolase 1 |
| Other gene symbols | DYT14 DYT5 DYT5a GCH GTP-CH-1 GTPCH1 HPABH4B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003934 | GTP cyclohydrolase I activity | IDA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006184 | GTP catabolic process | IDA | biological_process |
| GO:0006729 | Tetrahydrobiopterin biosynthetic process | IDA IMP | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | NAS | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0008217 | Regulation of blood pressure | IMP | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0014916 | Regulation of lung blood pressure | IEA | biological_process |
| GO:0030742 | GTP-dependent protein binding | IEA | molecular_function |
| GO:0031410 | Cytoplasmic vesicle | IDA | cellular_component |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | IDA IEP | biological_process |
| GO:0034341 | Response to interferon-gamma | IDA | biological_process |
| GO:0034612 | Response to tumor necrosis factor | IDA | biological_process |
| GO:0035998 | 7,8-dihydroneopterin 3'-triphosphate biosynthetic process | IEA | biological_process |
| GO:0042311 | Vasodilation | IEA | biological_process |
| GO:0042416 | Dopamine biosynthetic process | IDA | biological_process |
| GO:0042559 | Pteridine-containing compound biosynthetic process | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045776 | Negative regulation of blood pressure | IEA | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0046654 | Tetrahydrofolate biosynthetic process | IEA | biological_process |
| GO:0048265 | Response to pain | ISS | biological_process |
| GO:0050662 | Coenzyme binding | IEA | molecular_function |
| GO:0050884 | Neuromuscular process controlling posture | IMP | biological_process |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0051000 | Positive regulation of nitric-oxide synthase activity | IDA IMP | biological_process |
| GO:0051260 | Protein homooligomerization | IDA | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000855857 | 0.8573008320 | 0.0271409639 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7906910228 |
| GSE13712_SHEAR | Up | 0.2475223223 |
| GSE13712_STATIC | Up | 0.6225010155 |
| GSE19018 | Down | -1.4218278857 |
| GSE19899_A1 | Up | 1.3947640708 |
| GSE19899_A2 | Up | 4.5717798233 |
| PubMed_21979375_A1 | Up | 5.7231394935 |
| PubMed_21979375_A2 | Up | 5.4374989149 |
| GSE35957 | Up | 1.2352949749 |
| GSE36640 | Up | 0.4351768272 |
| GSE54402 | Up | 1.2145174565 |
| GSE9593 | Down | -0.3308134146 |
| GSE43922 | Up | 1.5777836111 |
| GSE24585 | Up | 0.4748891823 |
| GSE37065 | Up | 1.1019664581 |
| GSE28863_A1 | Up | 0.4590440716 |
| GSE28863_A2 | Up | 0.3271118967 |
| GSE28863_A3 | Down | -0.6986931698 |
| GSE28863_A4 | Up | 0.0054213662 |
| GSE48662 | Down | -0.0220670200 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002772 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018241 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022842 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024891 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026625 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029667 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050671 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
