HCSGD entry for GCG

1. General information

Official gene symbolGCG
Entrez ID2641
Gene full nameglucagon
Other gene symbolsGLP1 GLP2 GRPP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingTASmolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007631Feeding behaviorTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0010737Protein kinase A signalingIEAbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIEAbiological_process
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0034774Secretory granule lumenTAScellular_component
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045860Positive regulation of protein kinase activityIEAbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:0090280Positive regulation of calcium ion importIEAbiological_process
GO:1900118Negative regulation of execution phase of apoptosisIEAbiological_process
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46301140150.89920732870.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3176280489
GSE13712_SHEARUp0.0128441581
GSE13712_STATICUp0.0456511044
GSE19018Up0.1974634841
GSE19899_A1Up0.0472279646
GSE19899_A2Down-0.0324474009
PubMed_21979375_A1Up0.0423825471
PubMed_21979375_A2Down-0.0620349330
GSE35957Up0.0886194474
GSE36640Down-0.0090429312
GSE54402Down-0.0930047490
GSE9593Down-0.0153042718
GSE43922Up0.0421514039
GSE24585Up0.2270802373
GSE37065Up0.1088747559
GSE28863_A1Up0.0872329469
GSE28863_A2Down-0.0873189088
GSE28863_A3Up0.1289696761
GSE28863_A4Down-0.1386776437
GSE48662Up0.0806116547

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20448207Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A
20448207Here we investigated whether the antidiabetic hormone glucagon-like peptide 1 (GLP-1) could prevent oxidative stress-induced cellular senescence in endothelial cells
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