HCSGD entry for GNL3
1. General information
| Official gene symbol | GNL3 |
|---|---|
| Entrez ID | 26354 |
| Gene full name | guanine nucleotide binding protein-like 3 (nucleolar) |
| Other gene symbols | C77032 E2IG3 NNP47 NS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005730 | Nucleolus | IBA IEA ISS | cellular_component |
| GO:0006184 | GTP catabolic process | IBA | biological_process |
| GO:0008152 | Metabolic process | IBA | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA ISS | biological_process |
| GO:0042254 | Ribosome biogenesis | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8687928346 | 0.0460734395 | 0.9999902473 | 0.4029317608 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1369170911 |
| GSE13712_SHEAR | Up | 0.0178315660 |
| GSE13712_STATIC | Up | 0.2157843235 |
| GSE19018 | Down | -0.8806245372 |
| GSE19899_A1 | Up | 0.2682691830 |
| GSE19899_A2 | Down | -0.4725266165 |
| PubMed_21979375_A1 | Down | -1.7388893596 |
| PubMed_21979375_A2 | Down | -0.5485076452 |
| GSE35957 | Up | 0.5486460525 |
| GSE36640 | Down | -0.3888634629 |
| GSE54402 | Down | -0.5704787755 |
| GSE9593 | Up | 0.1486784033 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1801946459 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029281 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039623 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047156 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26722529 | Guanine nucleotide binding protein-like 3 is a potential prognosis indicator of gastric cancer |
| 26722529 | Guanine nucleotide binding protein-like 3 (GNL3) is a GIP-binding nuclear protein that has been reported to be involved in various biological processes, including cell proliferation, cellular senescence and tumorigenesis |
| 26722529 | This study aimed to investigate the expression level of GNL3 in gastric cancer and to evaluate the relationship between its expression and clinical variables and overall survival of gastric cancer patients |
| 26722529 | The expression level of GNL3 was examined in 89 human gastric cancer samples using immunohistochemistry (IHC) staining |
| 26722529 | GNL3 in gastric cancer tissues was significantly upregulated compared with paracancerous tissues |
| 26722529 | GNL3 expression in adjacent non-cancerous tissues was associated with sex and tumor size |
| 26722529 | Survival analyses showed that GNL3 expression in both gastric cancer and adjacent non-cancerous tissues were not related to overall survival |
| 26722529 | However, in the subgroup of patients with larger tumor size (>/= 6 cm), a close association was found between GNL3 expression in gastric cancer tissues and overall survival |
| 26722529 | Our study suggests that GNL3 might play an important role in the progression of gastric cancer and serve as a biomarker for poor prognosis in gastric cancer patients |
| 25882843 | Nuc-Pim1 enhances stem cell youthfulness associated with decreased senescence-associated beta-galactosidase activity, preserved telomere length, reduced expression of p16 and p53, and up-regulation of nucleostemin relative to PimWT hCPCs |
| 25593054 | Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging |
| 25593054 | Nucleostemin (NS) is a nucleolar protein regulating stem cell proliferation and pluripotency |
| 21464199 | Mechanistic studies revealed that CTP depletion induced a rapid translocation of nucleolar proteins, including nucleostemin and nucleolin into the nucleoplasm |
| 19501670 | Nucleostemin: a latecomer with new tricks |
| 19501670 | Nucleostemin was first identified in neural stem cells and has become a focus of research in cell cycle control, tumorigenesis and cellular senescence |
| 19501670 | As the biology of nucleostemin begins to be unveiled in multiple species, an ensuing task is to resolve the apparent differences between the functions of mammalian and invertebrate nucleostemin and its homologues, an issue of pressing interest given the role of nucleostemin in stem cell self-renewal and tissue regeneration |
| 19501670 | A genome-wide search reveals that nucleostemin and its closest homologue, GNL3L, only emerge as separate genes in vertebrates and possess conserved protein sequences as evolution proceeded to the Mammalia |
| 19501670 | The invertebrate orthologue of nucleostemin and GNL3L resembles GNL3L more than it does nucleostemin in function, raising the idea that nucleostemin acquires new properties while GNL3L inherits an evolutionarily fixed role, and that the birth of nucleostemin may signify the appearance of new functional features in the vertebrate lineage |
| 17473528 | The mRNA expressions of Smad3 increased, but those of c-myc and nucleostemin decreased with the length hMSCs were in in vitro culture |
| 17000763 | Nucleostemin (NS) encodes a nucleolar GTP-binding protein highly enriched in the stem cells and cancer cells |
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