HCSGD entry for GNL3


1. General information

Official gene symbolGNL3
Entrez ID26354
Gene full nameguanine nucleotide binding protein-like 3 (nucleolar)
Other gene symbolsC77032 E2IG3 NNP47 NS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEA ISSmolecular_function
GO:0005634NucleusISScellular_component
GO:0005654NucleoplasmIEAcellular_component
GO:0005730NucleolusIBA IEA ISScellular_component
GO:0006184GTP catabolic processIBAbiological_process
GO:0008152Metabolic processIBAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0042127Regulation of cell proliferationIEA ISSbiological_process
GO:0042254Ribosome biogenesisIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86879283460.04607343950.99999024730.4029317608

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1369170911
GSE13712_SHEARUp0.0178315660
GSE13712_STATICUp0.2157843235
GSE19018Down-0.8806245372
GSE19899_A1Up0.2682691830
GSE19899_A2Down-0.4725266165
PubMed_21979375_A1Down-1.7388893596
PubMed_21979375_A2Down-0.5485076452
GSE35957Up0.5486460525
GSE36640Down-0.3888634629
GSE54402Down-0.5704787755
GSE9593Up0.1486784033
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1801946459

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029281MicroarrayFunctional MTI (Weak)19088304
hsa-miR-615-3pMIMAT0003283MIRT039623CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047156CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26722529Guanine nucleotide binding protein-like 3 is a potential prognosis indicator of gastric cancer
26722529Guanine nucleotide binding protein-like 3 (GNL3) is a GIP-binding nuclear protein that has been reported to be involved in various biological processes, including cell proliferation, cellular senescence and tumorigenesis
26722529This study aimed to investigate the expression level of GNL3 in gastric cancer and to evaluate the relationship between its expression and clinical variables and overall survival of gastric cancer patients
26722529The expression level of GNL3 was examined in 89 human gastric cancer samples using immunohistochemistry (IHC) staining
26722529GNL3 in gastric cancer tissues was significantly upregulated compared with paracancerous tissues
26722529GNL3 expression in adjacent non-cancerous tissues was associated with sex and tumor size
26722529Survival analyses showed that GNL3 expression in both gastric cancer and adjacent non-cancerous tissues were not related to overall survival
26722529However, in the subgroup of patients with larger tumor size (>/= 6 cm), a close association was found between GNL3 expression in gastric cancer tissues and overall survival
26722529Our study suggests that GNL3 might play an important role in the progression of gastric cancer and serve as a biomarker for poor prognosis in gastric cancer patients
25882843Nuc-Pim1 enhances stem cell youthfulness associated with decreased senescence-associated beta-galactosidase activity, preserved telomere length, reduced expression of p16 and p53, and up-regulation of nucleostemin relative to PimWT hCPCs
25593054Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging
25593054Nucleostemin (NS) is a nucleolar protein regulating stem cell proliferation and pluripotency
21464199Mechanistic studies revealed that CTP depletion induced a rapid translocation of nucleolar proteins, including nucleostemin and nucleolin into the nucleoplasm
19501670Nucleostemin: a latecomer with new tricks
19501670Nucleostemin was first identified in neural stem cells and has become a focus of research in cell cycle control, tumorigenesis and cellular senescence
19501670As the biology of nucleostemin begins to be unveiled in multiple species, an ensuing task is to resolve the apparent differences between the functions of mammalian and invertebrate nucleostemin and its homologues, an issue of pressing interest given the role of nucleostemin in stem cell self-renewal and tissue regeneration
19501670A genome-wide search reveals that nucleostemin and its closest homologue, GNL3L, only emerge as separate genes in vertebrates and possess conserved protein sequences as evolution proceeded to the Mammalia
19501670The invertebrate orthologue of nucleostemin and GNL3L resembles GNL3L more than it does nucleostemin in function, raising the idea that nucleostemin acquires new properties while GNL3L inherits an evolutionarily fixed role, and that the birth of nucleostemin may signify the appearance of new functional features in the vertebrate lineage
17473528The mRNA expressions of Smad3 increased, but those of c-myc and nucleostemin decreased with the length hMSCs were in in vitro culture
17000763Nucleostemin (NS) encodes a nucleolar GTP-binding protein highly enriched in the stem cells and cancer cells
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