HCSGD entry for GBA
1. General information
| Official gene symbol | GBA |
|---|---|
| Entrez ID | 2629 |
| Gene full name | glucosidase, beta, acid |
| Other gene symbols | GBA1 GCB GLUC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004348 | Glucosylceramidase activity | IDA IEA | molecular_function |
| GO:0005102 | Receptor binding | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA IEA ISS TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA | biological_process |
| GO:0006665 | Sphingolipid metabolic process | IEA TAS | biological_process |
| GO:0006680 | Glucosylceramide catabolic process | IMP | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0009268 | Response to pH | IEA | biological_process |
| GO:0023021 | Termination of signal transduction | IMP | biological_process |
| GO:0032715 | Negative regulation of interleukin-6 production | IDA | biological_process |
| GO:0033561 | Regulation of water loss via skin | IEA | biological_process |
| GO:0033574 | Response to testosterone | IEA | biological_process |
| GO:0035307 | Positive regulation of protein dephosphorylation | IMP | biological_process |
| GO:0043202 | Lysosomal lumen | IEA ISS | cellular_component |
| GO:0043407 | Negative regulation of MAP kinase activity | IMP | biological_process |
| GO:0043589 | Skin morphogenesis | IEA | biological_process |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046512 | Sphingosine biosynthetic process | IMP | biological_process |
| GO:0046513 | Ceramide biosynthetic process | IMP | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | IC | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IMP | biological_process |
| GO:0097066 | Response to thyroid hormone | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1345389119 | 0.9636761027 | 0.7433246641 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Up | 0.3781945375 |
| GSE24585 | Up | 0.3763150025 |
| GSE37065 | Up | 0.4484551901 |
| GSE28863_A1 | Down | -0.0621933637 |
| GSE28863_A2 | Up | 0.5270352146 |
| GSE28863_A3 | Down | -0.3463218467 |
| GSE28863_A4 | Down | -0.2799495161 |
| GSE48662 | Up | 0.5257024775 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Myo-Inositol | DB03106 | EXPT01892 |
| N-acetyl-alpha-D-glucosamine | DB03740 | EXPT02319 |
| Velaglucerase alfa | DB06720 | - |
| (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL | DB08283 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-191-5p | MIMAT0000440 | MIRT045817 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16706651 | Among the most prevalent of these conditions are Gaucher disease and Fabry disease, which are caused by reduced activity of the housekeeping enzymes glucocerebrosidase and alpha-galactosidase A, respectively |
| 3695962 | The principles and methods used for enzymatic modification of the carbohydrate portion of glucocerebrosidase are similar to those performed by Ashwell and Morell, Stahl, and others |
| 3695962 | The principles demonstrated for the enzymatic deglycosylation of glucocerebrosidase may be applied to the cell-specific delivery of other glycoproteins as well |
| 3695962 | Animal and culture models have been developed for the study of glucocerebrosidase delivery to specific cell types and substrate degradation |
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