HCSGD entry for TINF2
1. General information
| Official gene symbol | TINF2 |
|---|---|
| Entrez ID | 26277 |
| Gene full name | TERF1 (TRF1)-interacting nuclear factor 2 |
| Other gene symbols | DKCA3 TIN2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA IEA | cellular_component |
| GO:0000783 | Nuclear telomere cap complex | IDA | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0010370 | Perinucleolar chromocenter | IDA | cellular_component |
| GO:0010833 | Telomere maintenance via telomere lengthening | IMP | biological_process |
| GO:0010836 | Negative regulation of protein ADP-ribosylation | IGI | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0032202 | Telomere assembly | IMP | biological_process |
| GO:0032205 | Negative regulation of telomere maintenance | IEA | biological_process |
| GO:0032206 | Positive regulation of telomere maintenance | IMP | biological_process |
| GO:0032211 | Negative regulation of telomere maintenance via telomerase | IC IGI | biological_process |
| GO:0034502 | Protein localization to chromosome | IC IMP | biological_process |
| GO:0042162 | Telomeric DNA binding | IDA | molecular_function |
| GO:0050680 | Negative regulation of epithelial cell proliferation | IMP | biological_process |
| GO:0070198 | Protein localization to chromosome, telomeric region | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2196362676 | 0.4508224384 | 0.9013168382 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6837199394 |
| GSE13712_SHEAR | Up | 0.0573353422 |
| GSE13712_STATIC | Down | -0.2611729259 |
| GSE19018 | Down | -0.3236113666 |
| GSE19899_A1 | Down | -0.1898675103 |
| GSE19899_A2 | Down | -0.1130736090 |
| PubMed_21979375_A1 | Up | 0.2641355331 |
| PubMed_21979375_A2 | Down | -0.4565120510 |
| GSE35957 | Down | -0.2730366792 |
| GSE36640 | Up | 0.0882091076 |
| GSE54402 | Up | 0.1201209552 |
| GSE9593 | Up | 0.0789287700 |
| GSE43922 | Up | 0.0355984284 |
| GSE24585 | Up | 0.6495237054 |
| GSE37065 | Up | 0.2357869507 |
| GSE28863_A1 | Up | 0.4714131258 |
| GSE28863_A2 | Up | 0.2150218957 |
| GSE28863_A3 | Down | -0.5320719618 |
| GSE28863_A4 | Up | 0.0260573070 |
| GSE48662 | Down | -0.1086872809 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030020 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27446538 | Other subunits, TERF1-interacting nuclear factor 2 and protection of telomeres protein 1, remained stable |
| 27349711 | Rapamycin treatment resulted in a significant decrease in DNA damage and a slight TIN2 increase |
| 27349711 | In vitro experiments strengthened in vivo results showing that rapamycin but not FK506 induced a significant DNA damage decrease and TIN2 expression increase compared with controls |
| 22932806 | A subset of patients, however, show mutations in the shelterin component TIN2, a TRF1-interacting protein, presenting a more severe phenotype and presence of very short telomeres despite normal telomerase activity |
| 22932806 | Importantly, increased compensatory proliferation of BM stem cells is associated with rapid telomere shortening and further increase in senescent cells in vivo, providing a mechanism for the very short telomeres of human patients with mutations in the shelterin TIN2 |
| 19229133 | A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix |
| 19229133 | Here we present evidence for a TIN2 isoform (TIN2L) that differs from the originally described TIN2 isoform (TIN2S) in two ways: TIN2L contains an additional 97 amino acids, and TIN2L associates strongly with the nuclear matrix |
| 19229133 | Stringent salt and detergent conditions failed to extract TIN2L from the nuclear matrix, despite removing other telomere components, including TIN2S |
| 15000677 | Chromosome telomeres of humans and many model organisms contain a structure called a t-loop, which is maintained by TERF, TINF2, Pot1, and other proteins |
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