HCSGD entry for FBXO5
1. General information
| Official gene symbol | FBXO5 |
|---|---|
| Entrez ID | 26271 |
| Gene full name | F-box protein 5 |
| Other gene symbols | EMI1 FBX5 Fbxo31 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001556 | Oocyte maturation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007057 | Spindle assembly involved in female meiosis I | IEA | biological_process |
| GO:0007091 | Metaphase/anaphase transition of mitotic cell cycle | TAS | biological_process |
| GO:0007346 | Regulation of mitotic cell cycle | ISS | biological_process |
| GO:0016050 | Vesicle organization | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0045835 | Negative regulation of meiosis | IEA | biological_process |
| GO:0046785 | Microtubule polymerization | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | IDA | biological_process |
| GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0060565 | Inhibition of mitotic anaphase-promoting complex activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9808791801 | 0.0000197409 | 0.9999902473 | 0.0084212121 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.1547678018 |
| GSE13712_SHEAR | Down | -0.0179612799 |
| GSE13712_STATIC | Down | -0.2342974260 |
| GSE19018 | Down | -0.3484721280 |
| GSE19899_A1 | Down | -2.1512593527 |
| GSE19899_A2 | Down | -3.7678357517 |
| PubMed_21979375_A1 | Down | -2.4493597220 |
| PubMed_21979375_A2 | Down | -5.0708363105 |
| GSE35957 | Down | -2.5957900551 |
| GSE36640 | Down | -4.4753491410 |
| GSE54402 | Down | -0.7113986961 |
| GSE9593 | Down | -1.6550415465 |
| GSE43922 | Down | -2.4593183987 |
| GSE24585 | Down | -0.5520413865 |
| GSE37065 | Up | 0.0441916598 |
| GSE28863_A1 | Down | -0.2485398299 |
| GSE28863_A2 | Up | 1.4251187004 |
| GSE28863_A3 | Down | -0.2375484664 |
| GSE28863_A4 | Up | 0.0755467235 |
| GSE48662 | Down | -1.4453438275 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016524 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT019510 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024627 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026894 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030275 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17875940 | Expression of the anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 is required for the accumulation of APC/C substrates crucial for DNA synthesis and mitotic entry |
| 17875940 | We show that in vivo Emi1 expression correlates with the proliferative status of the cellular compartment and that cells lacking Emi1 undergo cellular senescence |
| 17875940 | Emi1 depletion leads to strong decreases in E2F target mRNA and APC/C substrate protein abundances |
| 17875940 | Cells lacking Emi1 undergo DNA damage, likely explained by replication stress upon deregulated cyclin E- and A-associated kinase activities |
| 17875940 | Our data suggest that maintenance of a protein stabilization/mRNA expression positive-feedback circuit fueled by Emi1 is required for accurate cell cycle progression, maintenance of DNA integrity, and prevention of cellular senescence |
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