HCSGD entry for GATA4

1. General information

Official gene symbolGATA4
Entrez ID2626
Gene full nameGATA binding protein 4
Other gene symbolsASD2 VSD1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001076RNA polymerase II transcription factor binding transcription factor activityIDAmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0001706Endoderm formationIEAbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0003181Atrioventricular valve morphogenesisIEAbiological_process
GO:0003197Endocardial cushion developmentIEA IMP ISSbiological_process
GO:0003208Cardiac ventricle morphogenesisTASbiological_process
GO:0003215Cardiac right ventricle morphogenesisISSbiological_process
GO:0003229Ventricular cardiac muscle tissue developmentIEAbiological_process
GO:0003281Ventricular septum developmentISSbiological_process
GO:0003289Atrial septum primum morphogenesisISSbiological_process
GO:0003290Atrial septum secundum morphogenesisIMPbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA ISS NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007267Cell-cell signalingIEA ISSbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007492Endoderm developmentTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008584Male gonad developmentIEPbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010507Negative regulation of autophagyIEAbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionISSbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0033613Activating transcription factor bindingIEA ISSmolecular_function
GO:0035054Embryonic heart tube anterior/posterior pattern specificationIEA ISSbiological_process
GO:0035239Tube morphogenesisIEAbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEA ISSmolecular_function
GO:0043627Response to estrogenIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045766Positive regulation of angiogenesisISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA ISSbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048617Embryonic foregut morphogenesisIEA ISSbiological_process
GO:0051525NFAT protein bindingIEAmolecular_function
GO:0051891Positive regulation of cardioblast differentiationISSbiological_process
GO:0060008Sertoli cell differentiationIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0060413Atrial septum morphogenesisIMPbiological_process
GO:0060464Lung lobe formationIEAbiological_process
GO:0060575Intestinal epithelial cell differentiationIDAbiological_process
GO:0061049Cell growth involved in cardiac muscle cell developmentIEAbiological_process
GO:0070410Co-SMAD bindingIPImolecular_function
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071372Cellular response to follicle-stimulating hormone stimulusIEAbiological_process
GO:0072148Epithelial cell fate commitmentIEAbiological_process
GO:0072520Seminiferous tubule developmentIEAbiological_process
GO:0086004Regulation of cardiac muscle cell contractionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74331933820.84591952050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0528904461
GSE13712_SHEARDown-0.0119342782
GSE13712_STATICDown-0.0920400343
GSE19018Up0.0614172095
GSE19899_A1Up0.0763213262
GSE19899_A2Up0.0530368282
PubMed_21979375_A1Up0.0942393081
PubMed_21979375_A2Down-0.1511024527
GSE35957Up0.1194775224
GSE36640Up0.0499080180
GSE54402Down-0.0079887412
GSE9593Up0.0659744947
GSE43922Up0.1288640267
GSE24585Down-0.2580053799
GSE37065Down-0.0415278390
GSE28863_A1Down-0.0843265650
GSE28863_A2Up0.0563561496
GSE28863_A3Up0.3350794047
GSE28863_A4Up0.0509971049
GSE48662Up0.0221078349

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT000393Luciferase reporter assayFunctional MTI19188439
hsa-miR-200b-3pMIMAT0000318MIRT004008MicroarrayFunctional MTI (Weak)17875710
hsa-miR-34a-5pMIMAT0000255MIRT047394CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26404840The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
26404840We have identified the transcription factor GATA4 as a senescence and SASP regulator
26404840GATA4 is stabilized in cells undergoing senescence and is required for the SASP
26404840Normally, GATA4 is degraded by p62-mediated selective autophagy, but this regulation is suppressed during senescence, thereby stabilizing GATA4
26404840GATA4 in turn activates the transcription factor NF-kappaB to initiate the SASP and facilitate senescence
26404840GATA4 activation depends on the DNA damage response regulators ATM and ATR, but not on p53 or p16(INK4a)
26404840GATA4 accumulates in multiple tissues, including the aging brain, and could contribute to aging and its associated inflammation
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