HCSGD entry for KLHL3
1. General information
| Official gene symbol | KLHL3 |
|---|---|
| Entrez ID | 26249 |
| Gene full name | kelch-like family member 3 |
| Other gene symbols | PHA2D |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005198 | Structural molecule activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0016567 | Protein ubiquitination | IDA TAS | biological_process |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA TAS | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0050801 | Ion homeostasis | IMP | biological_process |
| GO:0070294 | Renal sodium ion absorption | IMP | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
| GO:0072156 | Distal tubule morphogenesis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6110962957 | 0.3035391892 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0539075063 |
| GSE13712_SHEAR | Down | -1.0542401736 |
| GSE13712_STATIC | Down | -0.8054496866 |
| GSE19018 | Up | 0.3035284169 |
| GSE19899_A1 | Up | 0.0428416631 |
| GSE19899_A2 | Up | 0.0695741699 |
| PubMed_21979375_A1 | Down | -0.3914443386 |
| PubMed_21979375_A2 | Up | 0.0682087073 |
| GSE35957 | Up | 0.4449789651 |
| GSE36640 | Down | -0.1045652018 |
| GSE54402 | Down | -0.1000449566 |
| GSE9593 | Down | -0.0003339549 |
| GSE43922 | Down | -0.0765730753 |
| GSE24585 | Down | -0.0303497318 |
| GSE37065 | Up | 0.0867999804 |
| GSE28863_A1 | Up | 0.0925871127 |
| GSE28863_A2 | Up | 0.0249463963 |
| GSE28863_A3 | Up | 0.0171553479 |
| GSE28863_A4 | Down | -0.0676824007 |
| GSE48662 | Up | 0.5680266026 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023657 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049738 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
