HCSGD entry for FBXL5
1. General information
| Official gene symbol | FBXL5 |
|---|---|
| Entrez ID | 26234 |
| Gene full name | F-box and leucine-rich repeat protein 5 |
| Other gene symbols | FBL4 FBL5 FLR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | NAS | cellular_component |
| GO:0004842 | Ubiquitin-protein ligase activity | NAS | molecular_function |
| GO:0005506 | Iron ion binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0016567 | Protein ubiquitination | IDA NAS | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | cellular_component |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0055072 | Iron ion homeostasis | IEP IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2269907222 | 0.3163573155 | 0.9085002280 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7569694482 |
| GSE13712_SHEAR | Down | -0.1001649165 |
| GSE13712_STATIC | Up | 0.0639886033 |
| GSE19018 | Up | 0.5979411920 |
| GSE19899_A1 | Up | 0.2276073120 |
| GSE19899_A2 | Down | -0.0534914293 |
| PubMed_21979375_A1 | Up | 0.3250949567 |
| PubMed_21979375_A2 | Up | 0.3695640460 |
| GSE35957 | Up | 0.9454304671 |
| GSE36640 | Up | 0.0223040812 |
| GSE54402 | Down | -0.3652182321 |
| GSE9593 | Up | 0.2727663525 |
| GSE43922 | Down | -0.0111161604 |
| GSE24585 | Up | 0.2211589039 |
| GSE37065 | Up | 0.2218439925 |
| GSE28863_A1 | Down | -0.3805256821 |
| GSE28863_A2 | Up | 0.0678612641 |
| GSE28863_A3 | Down | -0.5641303640 |
| GSE28863_A4 | Down | -0.1512731049 |
| GSE48662 | - | - |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020243 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021148 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028097 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043479 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
