HCSGD entry for GATA1

1. General information

Official gene symbolGATA1
Entrez ID2623
Gene full nameGATA binding protein 1 (globin transcription factor 1)
Other gene symbolsERYF1 GATA-1 GF-1 GF1 NFE1 XLANP XLTDA XLTT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIMPmolecular_function
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002039P53 bindingIEAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007267Cell-cell signalingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008301DNA binding, bendingIEAmolecular_function
GO:0008584Male gonad developmentIMPbiological_process
GO:0010559Regulation of glycoprotein biosynthetic processIMPbiological_process
GO:0010724Regulation of definitive erythrocyte differentiationIDAbiological_process
GO:0017053Transcriptional repressor complexIDAcellular_component
GO:0030218Erythrocyte differentiationIEPbiological_process
GO:0030219Megakaryocyte differentiationIMPbiological_process
GO:0030220Platelet formationIMPbiological_process
GO:0030221Basophil differentiationIEPbiological_process
GO:0030222Eosinophil differentiationIEPbiological_process
GO:0030502Negative regulation of bone mineralizationIEAbiological_process
GO:0031490Chromatin DNA bindingIDAmolecular_function
GO:0031965Nuclear membraneIDAcellular_component
GO:0033690Positive regulation of osteoblast proliferationIEAbiological_process
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0035854Eosinophil fate commitmentIDAbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEA IMPmolecular_function
GO:0045648Positive regulation of erythrocyte differentiationIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048821Erythrocyte developmentIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0070527Platelet aggregationIMPbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0071733Transcriptional activation by promoter-enhancer loopingISSbiological_process
GO:0097028Dendritic cell differentiationIEAbiological_process
GO:0097067Cellular response to thyroid hormone stimulusIDAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIDAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84251355950.67228609480.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0554649017
GSE13712_SHEARDown-0.0638255991
GSE13712_STATICDown-0.0618817530
GSE19018Down-0.0448860594
GSE19899_A1Down-0.1598482791
GSE19899_A2Down-0.1418807800
PubMed_21979375_A1Up0.0149455832
PubMed_21979375_A2Down-0.0688312004
GSE35957Up0.2177587045
GSE36640Down-0.0537251950
GSE54402Up0.0831618046
GSE9593Down-0.0618170937
GSE43922Up0.1208694074
GSE24585Down-0.0485108026
GSE37065Up0.0002571836
GSE28863_A1Down-0.0664836966
GSE28863_A2Up0.0322760844
GSE28863_A3Up0.2322443759
GSE28863_A4Up0.0448025004
GSE48662Up0.0311789133

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017923MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

9141625They also expressed RNA for beta-globin, GATA-1, and NF-E2
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