HCSGD entry for PHGDH
1. General information
| Official gene symbol | PHGDH |
|---|---|
| Entrez ID | 26227 |
| Gene full name | phosphoglycerate dehydrogenase |
| Other gene symbols | 3-PGDH 3PGDH PDG PGAD PGD PGDH SERA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004617 | Phosphoglycerate dehydrogenase activity | IEA TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006541 | Glutamine metabolic process | IEA | biological_process |
| GO:0006544 | Glycine metabolic process | IEA | biological_process |
| GO:0006564 | L-serine biosynthetic process | IEA TAS | biological_process |
| GO:0006566 | Threonine metabolic process | IEA | biological_process |
| GO:0007420 | Brain development | TAS | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0009448 | Gamma-aminobutyric acid metabolic process | IEA | biological_process |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0019530 | Taurine metabolic process | IEA | biological_process |
| GO:0021510 | Spinal cord development | IEA | biological_process |
| GO:0021782 | Glial cell development | IEA | biological_process |
| GO:0021915 | Neural tube development | IEA | biological_process |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051287 | NAD binding | IEA | molecular_function |
| GO:0070314 | G1 to G0 transition | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9681010980 | 0.0000334372 | 0.9999902473 | 0.0102337209 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0282549993 |
| GSE13712_SHEAR | Down | -0.7330587340 |
| GSE13712_STATIC | Down | -2.5296087756 |
| GSE19018 | Up | 0.8115448265 |
| GSE19899_A1 | Down | -1.2766031990 |
| GSE19899_A2 | Down | -2.7885385938 |
| PubMed_21979375_A1 | Down | -2.4089698822 |
| PubMed_21979375_A2 | Down | -3.8151767191 |
| GSE35957 | Down | -2.3179466290 |
| GSE36640 | Down | -2.7419454580 |
| GSE54402 | Down | -1.7284577291 |
| GSE9593 | Down | -0.4400713720 |
| GSE43922 | Down | -1.7820974021 |
| GSE24585 | Down | -0.0849022487 |
| GSE37065 | Down | -1.1262141375 |
| GSE28863_A1 | Up | 0.4306504793 |
| GSE28863_A2 | Down | -0.4853324873 |
| GSE28863_A3 | Down | -0.2248086183 |
| GSE28863_A4 | Down | -0.1807166917 |
| GSE48662 | Up | 0.3907707753 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020945 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030040 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036377 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038390 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039728 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043507 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-107 | MIMAT0000104 | MIRT048300 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
