HCSGD entry for GAS6

1. General information

Official gene symbolGAS6
Entrez ID2621
Gene full namegrowth arrest-specific 6
Other gene symbolsAXLLG AXSF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0001786Phosphatidylserine bindingIDAmolecular_function
GO:0001934Positive regulation of protein phosphorylationIDA ISSbiological_process
GO:0001961Positive regulation of cytokine-mediated signaling pathwayIMPbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0003104Positive regulation of glomerular filtrationISSbiological_process
GO:0005102Receptor bindingIDA IPImolecular_function
GO:0005245Voltage-gated calcium channel activityIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006508ProteolysisTASbiological_process
GO:0006909PhagocytosisIDAbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007165Signal transductionIDA TASbiological_process
GO:0007167Enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0009267Cellular response to starvationIEAbiological_process
GO:0010469Regulation of receptor activityIDAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0010934Macrophage cytokine productionIEAbiological_process
GO:0016477Cell migrationTASbiological_process
GO:0017187Peptidyl-glutamic acid carboxylationTASbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0019064Fusion of virus membrane with host plasma membraneIDAbiological_process
GO:0019079Viral genome replicationIDAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030296Protein tyrosine kinase activator activityIDAmolecular_function
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031100Organ regenerationIEAbiological_process
GO:0031589Cell-substrate adhesionIEAbiological_process
GO:0032008Positive regulation of TOR signalingISSbiological_process
GO:0032148Activation of protein kinase B activityISSbiological_process
GO:0032689Negative regulation of interferon-gamma productionIDAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0032825Positive regulation of natural killer cell differentiationIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0033159Negative regulation of protein import into nucleus, translocationIDAbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0035457Cellular response to interferon-alphaIDAbiological_process
GO:0035690Cellular response to drugIDAbiological_process
GO:0035754B cell chemotaxisIDAbiological_process
GO:0040008Regulation of growthIEAbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDAmolecular_function
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043277Apoptotic cell clearanceIDAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043491Protein kinase B signalingIDAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046718Viral entry into host cellIDAbiological_process
GO:0046813Receptor-mediated virion attachment to host cellIDAbiological_process
GO:0046827Positive regulation of protein export from nucleusIDAbiological_process
GO:0048018Receptor agonist activityIDAmolecular_function
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0050711Negative regulation of interleukin-1 secretionIDAbiological_process
GO:0050766Positive regulation of phagocytosisIDAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0060090Binding, bridgingIDAmolecular_function
GO:0061098Positive regulation of protein tyrosine kinase activityIDAbiological_process
GO:0070168Negative regulation of biomineral tissue developmentIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070527Platelet aggregationTASbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0071307Cellular response to vitamin KIDAbiological_process
GO:0071333Cellular response to glucose stimulusISSbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0072661Protein targeting to plasma membraneIDAbiological_process
GO:0085029Extracellular matrix assemblyISSbiological_process
GO:0097028Dendritic cell differentiationIEPbiological_process
GO:0097241Hematopoietic stem cell migration to bone marrowIDAbiological_process
GO:1900142Negative regulation of oligodendrocyte apoptotic processIDAbiological_process
GO:1900165Negative regulation of interleukin-6 secretionIDAbiological_process
GO:2000270Negative regulation of fibroblast apoptotic processIDAbiological_process
GO:2000273Positive regulation of receptor activityIDAbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIDAbiological_process
GO:2000510Positive regulation of dendritic cell chemotaxisIDAbiological_process
GO:2000533Negative regulation of renal albumin absorptionISSbiological_process
GO:2000669Negative regulation of dendritic cell apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37826945020.00009929330.99999024730.0175463087

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2225649634
GSE13712_SHEARDown-1.5149937080
GSE13712_STATICDown-0.9252359334
GSE19018Up1.0520827104
GSE19899_A1Down-4.2144789337
GSE19899_A2Down-2.5473670373
PubMed_21979375_A1Down-3.1838458555
PubMed_21979375_A2Down-3.1250880727
GSE35957Up0.4427949545
GSE36640Up1.3767584006
GSE54402Down-2.2359854942
GSE9593Up1.7162551035
GSE43922Down-2.1595459162
GSE24585Up0.0315977723
GSE37065Down-0.5363659581
GSE28863_A1Down-0.3384868045
GSE28863_A2Down-0.0421085630
GSE28863_A3Down-0.0813926212
GSE28863_A4Down-0.2464177723
GSE48662Up0.4487864098

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022472MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27783662METHODS: Correlations between expression of GAS6, a MERTK ligand, and prognosis were determined using data from the TCGA database
27783662RESULTS: Decreased overall survival significantly correlated with high levels of GAS6 expression in GBM, highlighting the importance of TAM kinase signaling in GBM tumorigenesis and/or therapy resistance and providing strong rationale for targeting these pathways in the clinic
27206970Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway
27206970Here, we tested the hypothesis that testosterone alleviated vascular smooth muscle cell (VSMC) senescence and collagen synthesis via growth arrest-specific protein 6 (Gas6)/Axl- and Akt/FoxO1a-dependent pathways
27206970The effects on VSMCs senescence and collagen synthesis were mediated by restoration of angiotensin II-induced downregulation of Gas6 and Axl expression and a subsequent reduction of Akt and FoxO1a phosphorylation
27206970The effects of testosterone were reversed by a Gas6 blocker, Axl-Fc, and a specific inhibitor of Axl, R428
27206970Taken together, Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis
25766527BACKGROUND/AIMS: Growth arrest-specific protein 6 (Gas6) is a cytokine that can be synthesized by a variety of cell types and secreted into the extracellular matrix
25766527Previous studies have confirmed that Gas6 is involved in certain pathophysiological processes of the cardiovascular system through binding to its receptor, Axl
25766527METHODS: We used vascular smooth muscle cells (VSMCs) to create two cellular senescence models, one for replicative senescence (RS) and one for induced senescence (IS), to test the hypothesis that Gas6 delays senescence
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