HCSGD entry for AMD1
1. General information
| Official gene symbol | AMD1 |
|---|---|
| Entrez ID | 262 |
| Gene full name | adenosylmethionine decarboxylase 1 |
| Other gene symbols | ADOMETDC AMD SAMDC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004014 | Adenosylmethionine decarboxylase activity | IEA TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006557 | S-adenosylmethioninamine biosynthetic process | IEA | biological_process |
| GO:0006595 | Polyamine metabolic process | TAS | biological_process |
| GO:0006597 | Spermine biosynthetic process | IEA | biological_process |
| GO:0008295 | Spermidine biosynthetic process | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2138535352 | 0.0696393526 | 0.8909210035 | 0.4980993210 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3427948285 |
| GSE13712_SHEAR | Up | 0.4905232632 |
| GSE13712_STATIC | Up | 0.0291523957 |
| GSE19018 | Down | -1.2784991688 |
| GSE19899_A1 | Up | 0.5158339382 |
| GSE19899_A2 | Up | 0.5142938718 |
| PubMed_21979375_A1 | Up | 0.2753095054 |
| PubMed_21979375_A2 | Up | 0.5110460630 |
| GSE35957 | Down | -0.5460797414 |
| GSE36640 | Down | -0.3359573489 |
| GSE54402 | Up | 0.4809256310 |
| GSE9593 | Down | -0.4340815669 |
| GSE43922 | Up | 0.2112356174 |
| GSE24585 | Down | -0.4250254589 |
| GSE37065 | Down | -0.0079860137 |
| GSE28863_A1 | Down | -0.2131338580 |
| GSE28863_A2 | Up | 0.0362103523 |
| GSE28863_A3 | Down | -0.6450246098 |
| GSE28863_A4 | Down | -0.1581955443 |
| GSE48662 | Down | -0.6013210320 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Putrescine | DB01917 | EXPT02702 |
| Tris | DB03754 | EXPT03072 |
| 5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine | DB08163 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-762 | MIMAT0010313 | MIRT006862 | Luciferase reporter assay | Functional MTI | 22391449 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021147 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042921 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050922 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
