HCSGD entry for PTPN22
1. General information
| Official gene symbol | PTPN22 |
|---|---|
| Entrez ID | 26191 |
| Gene full name | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
| Other gene symbols | LYP LYP1 LYP2 PEP PTPN8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004725 | Protein tyrosine phosphatase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IDA TAS | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | IDA IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA ISS | molecular_function |
| GO:0019900 | Kinase binding | IEA ISS | molecular_function |
| GO:0030217 | T cell differentiation | IEA ISS | biological_process |
| GO:0032817 | Regulation of natural killer cell proliferation | IDA | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | IDA | biological_process |
| GO:0035644 | Phosphoanandamide dephosphorylation | IEA ISS | biological_process |
| GO:0045088 | Regulation of innate immune response | IC | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050852 | T cell receptor signaling pathway | IEA | biological_process |
| GO:0050855 | Regulation of B cell receptor signaling pathway | NAS | biological_process |
| GO:0050860 | Negative regulation of T cell receptor signaling pathway | IDA | biological_process |
| GO:0050868 | Negative regulation of T cell activation | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0046007750 | 0.7632458911 | 0.1785238586 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3834171681 |
| GSE13712_SHEAR | Up | 0.0457344540 |
| GSE13712_STATIC | Up | 0.7738177033 |
| GSE19018 | Up | 0.0999189404 |
| GSE19899_A1 | Up | 0.1901473261 |
| GSE19899_A2 | Up | 0.8215329694 |
| PubMed_21979375_A1 | Up | 1.3598421343 |
| PubMed_21979375_A2 | Up | 2.2433279721 |
| GSE35957 | Up | 0.5257154759 |
| GSE36640 | Up | 0.1162205722 |
| GSE54402 | Up | 0.4018697474 |
| GSE9593 | Down | -0.2004465476 |
| GSE43922 | Up | 3.1800001758 |
| GSE24585 | Down | -0.1845148467 |
| GSE37065 | Up | 0.5825751679 |
| GSE28863_A1 | Down | -0.5527341423 |
| GSE28863_A2 | Up | 0.6547918096 |
| GSE28863_A3 | Down | -0.0802200432 |
| GSE28863_A4 | Down | -0.3661618862 |
| GSE48662 | Down | -0.2336973750 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181a-5p | MIMAT0000256 | MIRT006484 | Luciferase reporter assay//Western blot | Functional MTI | 17382377 |
| hsa-miR-1 | MIMAT0000416 | MIRT023898 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
