HCSGD entry for NOC2L
1. General information
| Official gene symbol | NOC2L |
|---|---|
| Entrez ID | 26155 |
| Gene full name | nucleolar complex associated 2 homolog (S. cerevisiae) |
| Other gene symbols | NET15 NET7 NIR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0002903 | Negative regulation of B cell apoptotic process | IMP | biological_process |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0031491 | Nucleosome binding | IDA | molecular_function |
| GO:0031497 | Chromatin assembly | IDA | biological_process |
| GO:0032066 | Nucleolus to nucleoplasm transport | IDA | biological_process |
| GO:0034644 | Cellular response to UV | IDA | biological_process |
| GO:0035067 | Negative regulation of histone acetylation | IDA | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0070491 | Repressing transcription factor binding | IDA | molecular_function |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0454381368 | 0.6688855477 | 0.4734668250 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0217544382 |
| GSE13712_SHEAR | Up | 0.4679480228 |
| GSE13712_STATIC | Up | 0.2987111953 |
| GSE19018 | Down | -0.3091675680 |
| GSE19899_A1 | Up | 0.1130501953 |
| GSE19899_A2 | Up | 0.8993418793 |
| PubMed_21979375_A1 | Up | 0.2640724365 |
| PubMed_21979375_A2 | Up | 0.7485087444 |
| GSE35957 | Down | -0.1461915246 |
| GSE36640 | Up | 0.1901179479 |
| GSE54402 | Up | 0.2428839061 |
| GSE9593 | Down | -0.2719067329 |
| GSE43922 | Up | 0.5168668174 |
| GSE24585 | Down | -0.7747902732 |
| GSE37065 | Down | -0.2517560428 |
| GSE28863_A1 | Up | 0.4934737106 |
| GSE28863_A2 | Up | 0.4470339534 |
| GSE28863_A3 | Up | 0.0648592108 |
| GSE28863_A4 | Down | -0.0713061042 |
| GSE48662 | Up | 0.1463739151 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023960 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040269 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042192 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045456 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049204 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050868 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27054782 | Given that beta-galactosidase (beta-gal) is an important biomarker for cell senescence and primary ovarian cancers, we design an enzyme-activatable ratiometric near-infrared (NIR) probe (DCM-betagal) for the real-time fluorescent quantification and trapping of beta-gal activity in vivo and in situ |
| 27054782 | DCM-betagal manifests significantly ratiometric and turn-on NIR fluorescent signals simultaneously in response to beta-gal concentration, which makes it favorable for monitoring dynamic beta-gal activity in vivo with self-calibration in fluorescent mode |
| 27054782 | Advantages of our system include light-up ratiometric NIR fluorescence with large Stokes shift, high photostability, and pH independency under the physiological range, allowing for the in vivo real-time evaluation of beta-gal activity at the tumor site with high-resolution three-dimensional bioimaging for the first time |
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