HCSGD entry for CHD5
1. General information
| Official gene symbol | CHD5 |
|---|---|
| Entrez ID | 26038 |
| Gene full name | chromodomain helicase DNA binding protein 5 |
| Other gene symbols | CHD-5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0016818 | Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5277159112 | 0.9081808328 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1152546257 |
| GSE13712_SHEAR | Down | -0.0385018958 |
| GSE13712_STATIC | Down | -0.1481793738 |
| GSE19018 | Up | 0.1116279448 |
| GSE19899_A1 | Up | 0.1795692749 |
| GSE19899_A2 | Up | 0.0255668848 |
| PubMed_21979375_A1 | Up | 0.2051298724 |
| PubMed_21979375_A2 | Down | -0.0994692164 |
| GSE35957 | Up | 0.2502924621 |
| GSE36640 | Up | 0.1027891971 |
| GSE54402 | Down | -0.0479259256 |
| GSE9593 | Down | -0.0126482210 |
| GSE43922 | Up | 0.1521191559 |
| GSE24585 | Up | 0.0840226381 |
| GSE37065 | Down | -0.1093583059 |
| GSE28863_A1 | Down | -0.1141209528 |
| GSE28863_A2 | Up | 0.0311845433 |
| GSE28863_A3 | Up | 0.2290336264 |
| GSE28863_A4 | Up | 0.0632124613 |
| GSE48662 | Up | 0.0150307424 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037503 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040349 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24529164 | CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma |
| 24529164 | BACKGROUND: Chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a potent tumour suppressor by acting as a master regulator of a tumour-suppressive network |
| 24529164 | BACKGROUND: Chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a potent tumour suppressor by acting as a master regulator of a tumour-suppressive network |
| 24529164 | Methylation-specific sequencing and methylation-specific PCR were performed to examine DNA methylation status of the CHD5 promoter in HCC cell lines and samples |
| 24529164 | The effect of CHD5 restoration on proliferation, colony formation, senescence, apoptosis and tumourigenicity were examined |
| 24529164 | RESULTS: CHD5 expression was sinificantly down-regulated in HCC cell lines and tissues examined, and the -841 to -470 region of CHD5 promoter was hypermethylated in these samples |
| 24529164 | RESULTS: CHD5 expression was sinificantly down-regulated in HCC cell lines and tissues examined, and the -841 to -470 region of CHD5 promoter was hypermethylated in these samples |
| 24529164 | Treatment with DNA methyltransferase inhibitor 5-aza-2-deoxycytidine resulted in a striking regional demethylation of the -841 to -470 region of CHD5 promoter and an increase in CHD5 expression |
| 24529164 | Treatment with DNA methyltransferase inhibitor 5-aza-2-deoxycytidine resulted in a striking regional demethylation of the -841 to -470 region of CHD5 promoter and an increase in CHD5 expression |
| 24529164 | The restoration of CHD5 expression inhibited tumour cell proliferation, colony formation and tumourigenicity and caused cellular senescence |
| 23168260 | JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5 |
| 23168260 | The expression of JMJD2A inhibits Ras-mediated CHD5 induction leading to a reduced activity of the p53 pathway |
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