HCSGD entry for SGMS1
1. General information
| Official gene symbol | SGMS1 |
|---|---|
| Entrez ID | 259230 |
| Gene full name | sphingomyelin synthase 1 |
| Other gene symbols | MOB MOB1 SMS1 TMEM23 hmob33 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000138 | Golgi trans cisterna | IDA | cellular_component |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006686 | Sphingomyelin biosynthetic process | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0016049 | Cell growth | IDA IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0030173 | Integral component of Golgi membrane | IDA | cellular_component |
| GO:0033188 | Sphingomyelin synthase activity | IEA IMP | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047493 | Ceramide cholinephosphotransferase activity | IDA | molecular_function |
| GO:0071222 | Cellular response to lipopolysaccharide | IEA | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IEA | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2009118840 | 0.0753689791 | 0.8646273411 | 0.5187727249 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5241834858 |
| GSE13712_SHEAR | Up | 0.6496319954 |
| GSE13712_STATIC | Up | 0.6561516110 |
| GSE19018 | Down | -0.0008861355 |
| GSE19899_A1 | Down | -0.9963031671 |
| GSE19899_A2 | Up | 0.0313129739 |
| PubMed_21979375_A1 | Up | 0.4205467467 |
| PubMed_21979375_A2 | Down | -0.4777379482 |
| GSE35957 | Up | 0.3547118698 |
| GSE36640 | Up | 1.0046317888 |
| GSE54402 | Down | -0.9156246153 |
| GSE9593 | Up | 0.4441662908 |
| GSE43922 | Down | -0.1040624476 |
| GSE24585 | Down | -0.2419362370 |
| GSE37065 | Up | 0.2092472917 |
| GSE28863_A1 | Up | 0.2967937189 |
| GSE28863_A2 | Down | -0.1887542633 |
| GSE28863_A3 | Down | -0.5232962105 |
| GSE28863_A4 | Up | 0.0454367042 |
| GSE48662 | Down | -0.0344432043 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020298 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022767 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027614 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028169 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028233 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037396 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
