HCSGD entry for ABI3BP
1. General information
| Official gene symbol | ABI3BP |
|---|---|
| Entrez ID | 25890 |
| Gene full name | ABI family, member 3 (NESH) binding protein |
| Other gene symbols | NESHBP TARSH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005518 | Collagen binding | IEA | molecular_function |
| GO:0005614 | Interstitial matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0010811 | Positive regulation of cell-substrate adhesion | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0167440903 | 0.2155965465 | 0.3193631884 | 0.8952069254 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0105079524 |
| GSE13712_SHEAR | Down | -0.5883222683 |
| GSE13712_STATIC | Down | -0.0005701432 |
| GSE19018 | Down | -0.1587803833 |
| GSE19899_A1 | Down | -0.0627624032 |
| GSE19899_A2 | Down | -0.8162162812 |
| PubMed_21979375_A1 | Down | -0.1306396468 |
| PubMed_21979375_A2 | Down | -1.1251496040 |
| GSE35957 | Down | -0.0272035404 |
| GSE36640 | Up | 0.0286416704 |
| GSE54402 | Down | -0.0835777206 |
| GSE9593 | Up | 1.1053410962 |
| GSE43922 | Down | -1.0979880316 |
| GSE24585 | Up | 0.4141137285 |
| GSE37065 | Up | 0.1231386804 |
| GSE28863_A1 | Up | 0.0422188991 |
| GSE28863_A2 | Up | 2.3759425710 |
| GSE28863_A3 | Up | 0.7871911886 |
| GSE28863_A4 | Up | 0.7151289129 |
| GSE48662 | Up | 0.7079594311 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21223585 | METHODS: The present study investigated ABI3 expression in a large panel of benign and malignant thyroid tumors and explored a correlation between the expression of ABI3 and its potential partner ABI3-binding protein (ABI3BP) |
| 21223585 | RESULTS: We not only observed that ABI3 expression is reduced or lost in most carcinomas but also that there is a positive correlation between ABI3 and ABI3BP expression |
| 19338757 | Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression |
| 19338757 | A novel target of NESH-SH3 (TARSH) was identified as a cellular senescence related gene in mouse embryonic fibroblasts (MEFs) replicative senescence, the expression of which has been suppressed in primary clinical lung cancer specimens |
| 19338757 | However, the molecular mechanism underlying the regulation of TARSH involved in pulmonary tumorigenesis remains unclear |
| 19338757 | Here we demonstrate that the reduction of TARSH gene expression by short hairpin RNA (shRNA) system robustly inhibited the MEFs proliferation with increase in senescence-associated beta-galactosidase (SA-beta-gal) activity |
| 19338757 | Using p53-/- MEFs, we further suggest that this growth arrest by loss of TARSH is evoked by p53-dependent p21(Cip1) accumulation |
| 19338757 | Moreover, we also reveal that TARSH reduction induces multicentrosome in MEFs, which is linked in chromosome instability and tumor development |
| 19338757 | These results suggest that TARSH plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development |
| 18559958 | Loss of ABI gene family member 3-binding protein (ABI3BP) expression may be functionally involved in the pathogenesis of cancer |
| 18559958 | We show here that ABI3BP expression is significantly decreased in most malignant thyroid tumors of all types |
| 18559958 | To better understand ABI3BP's role, we created a model by re-expressing ABI3BP in two thyroid cancer cell lines |
| 18559958 | Re-expression of ABI3BP in thyroid cells resulted in a decrease in transforming activity, cell growth, cell viability, migration, invasion, and tumor growth in nude mice |
| 18559958 | ABI3BP re-expression appears to trigger cellular senescence through the p21 pathway |
| 18559958 | Additionally, ABI3BP induced formation of heterochromatin 1-binding protein gamma-positive senescence-associated (SA) heterochromatin foci and accumulation of SA beta-galactosidase |
| 18559958 | The combination of a decrease in cell growth, invasion, and other effects upon ABI3BP re-expression in vitro helps to explain the large reduction in tumor growth that we observed in nude mice |
| 18559958 | Together, our data provide evidence that the loss of ABI3BP expression could play a functional role in thyroid tumorigenesis |
| 18559958 | Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers |
| 18158782 | Generation and characterization of novel monoclonal antibodies against murine and human TARSH proteins |
| 18158782 | TARSH/Abi3bp was originally isolated as a novel target of NESH-SH3 by a two-hybrid yeast system |
| 18158782 | We have already identified murine TARSH (mTARSH) as a cellular senescence-related gene because of its robust induction in the early phase of mouse embryonic fibroblast cellular senescence |
| 18158782 | This evidence suggests that TARSH is involved in both stress-induced senescence and prevention of cancer development; however, little is known about its molecular mechanisms |
| 18158782 | Recombinant His-tagged partial mouse TARSH protein was expressed in Escherichia coli, affinity purified and used as an antigen to immunize rats |
| 18158782 | Hybridomas were screened by enzyme-linked immunosorbent assay, and we generated six stable hybridoma cell lines that produced antibody against murine TARSH protein, including three clones that represented cross-reactivity with human TARSH |
| 18158782 | These MAbs should therefore be very useful tools for the study of TARSH expression and for following biological function in cellular senescence and tumor suppression |
| 16205947 | Cancer-associated loss of TARSH gene expression in human primary lung cancer |
| 16205947 | PURPOSE: We have previously identified mouse Tarsh as one of the cellular senescence-related genes and showed the loss of expression of TARSH mRNA in four human lung cancer cell lines |
| 16205947 | TARSH is a presumptive signal transduction molecule interacting with NESH, which is implicated to have some roles in lung cancer metastasis |
| 16205947 | METHODS: The amplification of complete ORF-encoding TARSH cDNA was done with reverse transcription-PCR |
| 16205947 | Northern blotting was carried out using TARSH cDNA probes |
| 16205947 | To clarify the relationship between TARSH and lung cancer, we quantified TARSH mRNA expression in 15 human lung cancer cell lines and 32 primary non-small cell lung cancers |
| 16205947 | On the Northern hybridization analysis, TARSH was strongly expressed in the human lung |
| 16205947 | The expression of TARSH mRNA is remarkably downregulated in all the lung cancer cell lines examined |
| 16205947 | Furthermore, TARSH expression was significantly low in all of the tumor specimens when compared to the expression in corresponding non-neoplastic lung tissue specimens |
| 16205947 | CONCLUSION: The cancer-associated transcriptional inactivation of TARSH suggests that TARSH could be used as a biomarker for lung cancer development as well as a molecular adjunct for lung carcinogenesis in human |
| 15752759 | Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer |
| 15752759 | We show here that mTARSH was induced particularly in the relative early phase of MEFs cellular senescence |
| 15752759 | Further structural analysis of mTARSH disclosed five splicing variants shared a common reading frame whose diversity was derived from the SH3-binding motif cluster in the middle of the gene |
| 15752759 | We also show that mTARSH mRNA predominantly expressed in lung and that conspicuous expression of TARSH was drastically declined in all several lung cancer cell lines we tested |
| 15752759 | Thus, TARSH presumably represents a trigger gene for evoking cellular senescence, which has also been suggested to be involved in the prevention of tumorigenesis |
Entries Per Page
Displaying Page of
