HCSGD entry for PRKD2

1. General information

Official gene symbolPRKD2
Entrez ID25865
Gene full nameprotein kinase D2
Other gene symbolsPKD2 nPKC-D2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIGI IMPbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA NASmolecular_function
GO:0004697Protein kinase C activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0008219Cell deathIMPbiological_process
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0030949Positive regulation of vascular endothelial growth factor receptor signaling pathwayIMPbiological_process
GO:0032743Positive regulation of interleukin-2 productionIEA ISSbiological_process
GO:0032757Positive regulation of interleukin-8 productionIMPbiological_process
GO:0032793Positive regulation of CREB transcription factor activityIGIbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIGIbiological_process
GO:0035556Intracellular signal transductionIEA IGI IMPbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIGI IMPbiological_process
GO:0038033Positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayIGI IMPbiological_process
GO:0043536Positive regulation of blood vessel endothelial cell migrationIGI IMPbiological_process
GO:0045743Positive regulation of fibroblast growth factor receptor signaling pathwayIMPbiological_process
GO:0045766Positive regulation of angiogenesisIGI IMPbiological_process
GO:0045785Positive regulation of cell adhesionIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046777Protein autophosphorylationIDA TASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIMPbiological_process
GO:0050852T cell receptor signaling pathwayIDAbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayIEA ISSbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0061154Endothelial tube morphogenesisTASbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEA ISSbiological_process
GO:1901727Positive regulation of histone deacetylase activityIGIbiological_process
GO:1902533Positive regulation of intracellular signal transductionIMPbiological_process
GO:2000573Positive regulation of DNA biosynthetic processIEA ISSbiological_process
GO:2001028Positive regulation of endothelial cell chemotaxisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17129150110.85928325670.81364676401.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3252976502
GSE13712_SHEARDown-0.2205166803
GSE13712_STATICDown-0.1672936362
GSE19018Up0.1564964861
GSE19899_A1Up0.1130200520
GSE19899_A2Up0.0983013654
PubMed_21979375_A1Up0.7013862409
PubMed_21979375_A2Up1.2606810226
GSE35957Down-0.4439058108
GSE36640Down-0.1196342364
GSE54402Down-0.0281984424
GSE9593Down-0.0389179763
GSE43922Up0.0350893716
GSE24585Down-0.2251801046
GSE37065Up0.4624903826
GSE28863_A1Up0.0800362906
GSE28863_A2Down-0.0501950207
GSE28863_A3Up0.1829604944
GSE28863_A4Down-0.0104430521
GSE48662Up0.3987206968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004187MicroarrayFunctional MTI (Weak)16822819
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24463355Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways
24463355Aberrant protein kinase C (PKC) signaling has been implicated in gliomagenesis, and a member of the PKC-activated protein kinase D (PRKD) family, PRKD2, was identified as mediator of GBM growth in vitro and in vivo
24463355METHODS: The outcome of PRKD2 silencing and pharmacological inhibition on glioma cell proliferation was established with different glioma cell lines
24463355RESULTS: RNA-interference (21-mer siRNA) and pharmacological inhibition (CRT0066101) of PRKD2 profoundly inhibited proliferation of p53(wt) (U87MG, A172, and primary GBM2), and p53(mut) (GM133, T98G, U251, and primary Gli25) glioma cells
24463355In a xenograft experiment, PRKD2 silencing significantly delayed tumor growth of U87MG cells
24463355PRKD2 silencing in p53(wt) and p53(mut) cells was associated with typical hallmarks of senescence and cell cycle arrest in G1
24463355Attenuated AKT/PKB phosphorylation in response to PRKD2 silencing was a common observation made in p53(wt) and p53(mut) GBM cells
24463355CONCLUSIONS: PRKD2 silencing induces glioma cell senescence via p53-dependent and -independent pathways
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