HCSGD entry for ASF1A
1. General information
| Official gene symbol | ASF1A |
|---|---|
| Entrez ID | 25842 |
| Gene full name | anti-silencing function 1A histone chaperone |
| Other gene symbols | CGI-98 CIA HSPC146 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001649 | Osteoblast differentiation | IEA | biological_process |
| GO:0003682 | Chromatin binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006334 | Nucleosome assembly | IDA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0031936 | Negative regulation of chromatin silencing | NAS | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0042692 | Muscle cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9517041450 | 0.0231030812 | 0.9999902473 | 0.2923539423 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6324484996 |
| GSE13712_SHEAR | Up | 0.0119017545 |
| GSE13712_STATIC | Up | 0.0003714534 |
| GSE19018 | Up | 0.1689573021 |
| GSE19899_A1 | Down | -0.2157817973 |
| GSE19899_A2 | Down | -0.8029648081 |
| PubMed_21979375_A1 | Down | -0.2788903435 |
| PubMed_21979375_A2 | Down | -0.6512047431 |
| GSE35957 | Down | -0.4519886412 |
| GSE36640 | Down | -0.6619230683 |
| GSE54402 | Up | 0.0399193503 |
| GSE9593 | Down | -0.4701772641 |
| GSE43922 | Up | 0.0005602597 |
| GSE24585 | Down | -0.3678021397 |
| GSE37065 | Up | 0.0633998536 |
| GSE28863_A1 | Down | -0.1649390869 |
| GSE28863_A2 | Up | 0.1315869334 |
| GSE28863_A3 | Down | -0.6900835728 |
| GSE28863_A4 | Down | -0.1900691947 |
| GSE48662 | Down | -0.5816218973 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019628 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020266 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028099 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19029251 | Formation of SAHF in human cells is driven by a complex of histone chaperones, namely, HIRA and ASF1a |
| 17643369 | Formation of SAHF is driven by a complex of histone chaperones, HIRA and ASF1a, and depends upon prior localization of HIRA to PML nuclear bodies |
| 17242207 | Previously, we showed that a complex of histone chaperones, histone repressor A (HIRA) and antisilencing function 1a (ASF1a), plays a key role in the formation of SAHF |
| 17242207 | Chromosome condensation depends on the ability of ASF1a to physically interact with its deposition substrate, histone H3, in addition to its cochaperone, HIRA |
| 17242198 | HIRA bound to another histone chaperone, ASF1a, drives formation of SAHF |
| 16980972 | The HIRA B domain forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a, via beta-sheet, salt bridge and van der Waals contacts |
| 16980972 | The N- and C-terminal regions of ASF1a and ASF1b determine the different affinities of these two proteins for HIRA, by contacting regions outside the HIRA B domain |
| 15621527 | Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA |
| 15621527 | A physical complex containing HIRA and another chromatin regulator, ASF1a, is rate limiting for formation of SAHF and onset of senescence, and ASF1a is required for formation of SAHF and efficient senescence-associated cell cycle exit |
| 15621527 | These data indicate that HIRA and ASF1a drive formation of macroH2A-containing SAHF and senescence-associated cell cycle exit, via a pathway that appears to depend on flux of heterochromatic proteins through PML bodies |
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