HCSGD entry for NIPBL
1. General information
| Official gene symbol | NIPBL |
|---|---|
| Entrez ID | 25836 |
| Gene full name | Nipped-B homolog (Drosophila) |
| Other gene symbols | CDLS CDLS1 IDN3 IDN3-B Scc2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001656 | Metanephros development | NAS | biological_process |
| GO:0003007 | Heart morphogenesis | IMP | biological_process |
| GO:0003151 | Outflow tract morphogenesis | IMP | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0007064 | Mitotic sister chromatid cohesion | IMP | biological_process |
| GO:0007420 | Brain development | IMP | biological_process |
| GO:0007605 | Sensory perception of sound | IMP | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0031065 | Positive regulation of histone deacetylation | IDA | biological_process |
| GO:0032116 | SMC loading complex | IDA | cellular_component |
| GO:0034088 | Maintenance of mitotic sister chromatid cohesion | IMP | biological_process |
| GO:0034613 | Cellular protein localization | IMP | biological_process |
| GO:0035115 | Embryonic forelimb morphogenesis | IMP | biological_process |
| GO:0035136 | Forelimb morphogenesis | IMP | biological_process |
| GO:0035261 | External genitalia morphogenesis | IMP | biological_process |
| GO:0036033 | Mediator complex binding | IEA | molecular_function |
| GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
| GO:0042471 | Ear morphogenesis | IMP | biological_process |
| GO:0042634 | Regulation of hair cycle | IMP | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0045444 | Fat cell differentiation | IEA | biological_process |
| GO:0045778 | Positive regulation of ossification | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045995 | Regulation of embryonic development | IMP | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0048557 | Embryonic digestive tract morphogenesis | IMP | biological_process |
| GO:0048589 | Developmental growth | IMP | biological_process |
| GO:0048592 | Eye morphogenesis | IMP | biological_process |
| GO:0048638 | Regulation of developmental growth | IMP | biological_process |
| GO:0048703 | Embryonic viscerocranium morphogenesis | IEA | biological_process |
| GO:0050890 | Cognition | IMP | biological_process |
| GO:0060325 | Face morphogenesis | IMP | biological_process |
| GO:0061010 | Gall bladder development | IMP | biological_process |
| GO:0061038 | Uterus morphogenesis | IMP | biological_process |
| GO:0070087 | Chromo shadow domain binding | IPI | molecular_function |
| GO:0071481 | Cellular response to X-ray | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5074105847 | 0.0931297937 | 0.9999902473 | 0.5811449265 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1085336995 |
| GSE13712_SHEAR | Down | -0.0103734849 |
| GSE13712_STATIC | Down | -0.0957221768 |
| GSE19018 | Up | 0.1155659991 |
| GSE19899_A1 | Down | -0.1725548452 |
| GSE19899_A2 | Down | -0.6049522231 |
| PubMed_21979375_A1 | Up | 0.0148334205 |
| PubMed_21979375_A2 | Down | -0.1413577943 |
| GSE35957 | Down | -0.1190386628 |
| GSE36640 | Down | -0.6210559289 |
| GSE54402 | Up | 0.0507864366 |
| GSE9593 | Down | -0.1219060774 |
| GSE43922 | Down | -0.2241421305 |
| GSE24585 | Up | 0.4708067985 |
| GSE37065 | Up | 0.1013640643 |
| GSE28863_A1 | Up | 0.7391579836 |
| GSE28863_A2 | Up | 0.9049406075 |
| GSE28863_A3 | Down | -0.6203166713 |
| GSE28863_A4 | Down | -0.3794847136 |
| GSE48662 | Down | -0.2918736775 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003175 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-421 | MIMAT0003339 | MIRT016135 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030681 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032211 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040938 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046116 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047113 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052641 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
