HCSGD entry for FBXL2
1. General information
| Official gene symbol | FBXL2 |
|---|---|
| Entrez ID | 25827 |
| Gene full name | F-box and leucine-rich repeat protein 2 |
| Other gene symbols | FBL2 FBL3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006508 | Proteolysis | TAS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0006513 | Protein monoubiquitination | IEA | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0387835759 | 0.7272017401 | 0.4442262402 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3516728589 |
| GSE13712_SHEAR | Up | 0.5983681580 |
| GSE13712_STATIC | Up | 0.6887292152 |
| GSE19018 | Up | 0.4808296011 |
| GSE19899_A1 | Down | -0.1458033267 |
| GSE19899_A2 | Up | 0.3165129066 |
| PubMed_21979375_A1 | Down | -0.8789399236 |
| PubMed_21979375_A2 | Down | -0.0849641107 |
| GSE35957 | Down | -0.1048929498 |
| GSE36640 | Up | 1.3294603702 |
| GSE54402 | Down | -0.2808411097 |
| GSE9593 | Up | 0.6295549418 |
| GSE43922 | Down | -0.6476168978 |
| GSE24585 | Up | 0.2638208310 |
| GSE37065 | Down | -0.1720089780 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1901941077 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030985 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042990 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
