HCSGD entry for PRDX5

1. General information

Official gene symbolPRDX5
Entrez ID25824
Gene full nameperoxiredoxin 5
Other gene symbolsACR1 AOEB166 B166 PLP PMP20 PRDX6 PRXV prx-V
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001016RNA polymerase III regulatory region DNA bindingIDAmolecular_function
GO:0004601Peroxidase activityIDAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005777PeroxisomeIDAcellular_component
GO:0005782Peroxisomal matrixIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006954Inflammatory responseTASbiological_process
GO:0006979Response to oxidative stressIDAbiological_process
GO:0010466Negative regulation of peptidase activityIMPbiological_process
GO:0010951Negative regulation of endopeptidase activityIMPbiological_process
GO:0016209Antioxidant activityIDAmolecular_function
GO:0016480Negative regulation of transcription from RNA polymerase III promoterIDAbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0032967Positive regulation of collagen biosynthetic processIDAbiological_process
GO:0034614Cellular response to reactive oxygen speciesIMPbiological_process
GO:0042744Hydrogen peroxide catabolic processIDAbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIMPmolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043086Negative regulation of catalytic activityIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050790Regulation of catalytic activityIMPbiological_process
GO:0051354Negative regulation of oxidoreductase activityIDAbiological_process
GO:0051920Peroxiredoxin activityIDA IEAmolecular_function
GO:0052547Regulation of peptidase activityIMPbiological_process
GO:0052548Regulation of endopeptidase activityIMPbiological_process
GO:0060785Regulation of apoptosis involved in tissue homeostasisIDAbiological_process
GO:0070995NADPH oxidationIDAbiological_process
GO:0072541Peroxynitrite reductase activityIDAmolecular_function
GO:2001057Reactive nitrogen species metabolic processIDAbiological_process
GO:2001141Regulation of RNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15467698420.60843656020.78221161231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1855550004
GSE13712_SHEARUp0.0560973431
GSE13712_STATICDown-0.0529939899
GSE19018Up0.2707543311
GSE19899_A1Up0.5069099959
GSE19899_A2Up0.2263813014
PubMed_21979375_A1Down-0.1205505658
PubMed_21979375_A2Up0.1920111830
GSE35957Down-0.1867105554
GSE36640Up0.2418986880
GSE54402Down-0.0092774638
GSE9593Up0.2270450037
GSE43922Up0.1984034329
GSE24585Up0.3481159539
GSE37065Down-0.1487715948
GSE28863_A1Down-0.4430806629
GSE28863_A2Down-0.5095356620
GSE28863_A3Down-0.0991584785
GSE28863_A4Up0.1966186031
GSE48662Down-0.0303814176

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AuranofinDB00995 APRD00808
DiminazeneDB03608 EXPT00754
Benzoic AcidDB03793 EXPT00675

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037717CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.