HCSGD entry for ATXN10
1. General information
| Official gene symbol | ATXN10 |
|---|---|
| Entrez ID | 25814 |
| Gene full name | ataxin 10 |
| Other gene symbols | E46L HUMEEP SCA10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0007399 | Nervous system development | IMP | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0030425 | Dendrite | IDA | cellular_component |
| GO:0031175 | Neuron projection development | IDA | biological_process |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043025 | Neuronal cell body | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9755649861 | 0.0281939820 | 0.9999902473 | 0.3198680172 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1643650325 |
| GSE13712_SHEAR | Down | -0.4311687266 |
| GSE13712_STATIC | Down | -0.1154356265 |
| GSE19018 | Up | 0.0079076580 |
| GSE19899_A1 | Down | -0.6152916031 |
| GSE19899_A2 | Down | -0.4822731423 |
| PubMed_21979375_A1 | Down | -0.9672431999 |
| PubMed_21979375_A2 | Down | -0.4631363056 |
| GSE35957 | Up | 0.4842207637 |
| GSE36640 | Up | 0.2188150773 |
| GSE54402 | Down | -0.2250712292 |
| GSE9593 | Up | 0.0967660449 |
| GSE43922 | Down | -0.2084914867 |
| GSE24585 | Up | 0.0421835555 |
| GSE37065 | Down | -0.0131430349 |
| GSE28863_A1 | Down | -0.0115215166 |
| GSE28863_A2 | Down | -0.2315686407 |
| GSE28863_A3 | Down | -0.6831618999 |
| GSE28863_A4 | Up | 0.1026254971 |
| GSE48662 | Down | -0.4083987511 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020830 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028592 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046248 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21740549 | Comparison of these known targets with genes known to be up-regulated upon senescence in these cells, by micro-array expression profiling, identified 4 common genes TMEM9B, ATXN10, LAYN and LTBP2/3 |
| 21740549 | CONCLUSION: The senescence bypass screen identified TMEM9B, ATXN10, LAYN and LTBP2/3 as novel downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways |
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