HCSGD entry for RASGRP3

1. General information

Official gene symbolRASGRP3
Entrez ID25780
Gene full nameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Other gene symbolsGRP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeNASbiological_process
GO:0004871Signal transducer activityTASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIEA TASmolecular_function
GO:0005088Ras guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005509Calcium ion bindingNASmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0017016Ras GTPase bindingIEAmolecular_function
GO:0019900Kinase bindingIEAmolecular_function
GO:0019992Diacylglycerol bindingNASmolecular_function
GO:0032045Guanyl-nucleotide exchange factor complexIEAcellular_component
GO:0032320Positive regulation of Ras GTPase activityIDAbiological_process
GO:0032854Positive regulation of Rap GTPase activityIDAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0046582Rap GTPase activator activityIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12009495460.40143313320.70892284751.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0747345370
GSE13712_SHEARDown-0.8946742783
GSE13712_STATICDown-0.2023785775
GSE19018Down-0.1152345228
GSE19899_A1Up0.2190457904
GSE19899_A2Down-0.0382401369
PubMed_21979375_A1Down-0.2480265463
PubMed_21979375_A2Down-0.0730649588
GSE35957Up0.0647296402
GSE36640Up1.0541394495
GSE54402Up1.0227365307
GSE9593Down-0.0888506993
GSE43922Up0.0243322368
GSE24585Up0.6912389793
GSE37065Up0.6655794857
GSE28863_A1Down-0.5817450669
GSE28863_A2Down-0.0925701324
GSE28863_A3Down-0.0257908076
GSE28863_A4Up0.2363146426
GSE48662Down-0.1113921680

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030769MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.