HCSGD entry for G6PD
1. General information
| Official gene symbol | G6PD |
|---|---|
| Entrez ID | 2539 |
| Gene full name | glucose-6-phosphate dehydrogenase |
| Other gene symbols | G6PD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001816 | Cytokine production | IMP | biological_process |
| GO:0004345 | Glucose-6-phosphate dehydrogenase activity | IDA IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005536 | Glucose binding | IDA IEA IMP | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA IEA TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006098 | Pentose-phosphate shunt | IDA IEA TAS | biological_process |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | IMP | biological_process |
| GO:0006739 | NADP metabolic process | IDA | biological_process |
| GO:0006740 | NADPH regeneration | IMP | biological_process |
| GO:0006749 | Glutathione metabolic process | IMP | biological_process |
| GO:0009051 | Pentose-phosphate shunt, oxidative branch | IEA IMP | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0010734 | Negative regulation of protein glutathionylation | IMP | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0019322 | Pentose biosynthetic process | IDA | biological_process |
| GO:0032094 | Response to food | IEA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043249 | Erythrocyte maturation | IMP | biological_process |
| GO:0043523 | Regulation of neuron apoptotic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0046390 | Ribose phosphate biosynthetic process | IMP | biological_process |
| GO:0050661 | NADP binding | IDA IEA | molecular_function |
| GO:0051156 | Glucose 6-phosphate metabolic process | IDA IEA IMP | biological_process |
| GO:0055114 | Oxidation-reduction process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8169412370 | 0.0135198891 | 0.9999902473 | 0.2293416237 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4916020425 |
| GSE13712_SHEAR | Down | -0.3164060452 |
| GSE13712_STATIC | Down | -0.2541812876 |
| GSE19018 | Down | -0.5117760293 |
| GSE19899_A1 | Down | -2.0551378895 |
| GSE19899_A2 | Down | -1.4209912264 |
| PubMed_21979375_A1 | Down | -0.8185341478 |
| PubMed_21979375_A2 | Down | -0.3981070422 |
| GSE35957 | Down | -0.6357852401 |
| GSE36640 | Up | 0.0295643916 |
| GSE54402 | Down | -0.2257090302 |
| GSE9593 | Down | -0.0595623521 |
| GSE43922 | Down | -0.7438618192 |
| GSE24585 | Down | -0.0683292019 |
| GSE37065 | Down | -0.2439651726 |
| GSE28863_A1 | Up | 0.3083345630 |
| GSE28863_A2 | Up | 0.2408053900 |
| GSE28863_A3 | Down | -0.2181036151 |
| GSE28863_A4 | Up | 0.1268491116 |
| GSE48662 | Up | 0.6406267157 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL90593 | CHEMBL5347 | 9 | P11413 |
| CHEMBL272195 | CHEMBL5347 | 9 | P11413 |
| CHEMBL90593 | CHEMBL5347 | 9 | P11413 |
| CHEMBL272195 | CHEMBL5347 | 9 | P11413 |
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Hydroxyacetic Acid | DB03085 | EXPT01629 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
| 16-Bromoepiandrosterone | DB05107 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002956 | Luciferase reporter assay | Functional MTI | 14697198 |
| hsa-miR-1 | MIMAT0000416 | MIRT002956 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT002956 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018235 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029662 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040672 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 25 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25960715 | Every week an aliquot was collected for laboratorial evaluation, which included complete cell blood count, glucose-6-phosphate dehydrogenase (G6PD) activity, extracellular sodium, potassium and pH, membrane-bound hemoglobin (MBH), band 3 profile, and quantification of RBC membrane proteins composition |
| 25937285 | This was due to restoration of deoxyribonucleotide triphosphate (dNTP) levels through both upregulation of the pentose phosphate pathway via increased glucose-6-phosphate dehydrogenase (G6PD) activity and enhanced glucose and glutamine consumption |
| 25937285 | This was due to restoration of deoxyribonucleotide triphosphate (dNTP) levels through both upregulation of the pentose phosphate pathway via increased glucose-6-phosphate dehydrogenase (G6PD) activity and enhanced glucose and glutamine consumption |
| 23941874 | Our results demonstrated that the total antioxidant capacity and mRNA levels of thioredoxinreductase and glucose-6-phosphate dehydrogenase as well as the ratio of NADPH/NADP were decreased markedly in fibroblasts from patients with type 2 diabetes (DFs) |
| 21474668 | Tyrosine phosphorylation of band 3 is induced by several physiologic stimuli, including malaria parasite invasion, cell shrinkage, normal cell aging, and oxidant stress (thalassemias, sickle cell disease, glucose-6-phosphate dehydrogenase deficiency, etc) |
| 20473639 | Glucose-6-phosphate dehydrogenase was lowest in log-phase cells exposed to different oxygen tensions for 24 h and in senescent cells |
| 19272180 | Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts |
| 19272180 | Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition |
| 18513544 | Glucose-6-phosphate dehydrogenase (G6PD) is a determinant in the antioxidant status of the red blood cell (RBC) and is also used as an indicator of cell age |
| 18513544 | Glucose-6-phosphate dehydrogenase (G6PD) is a determinant in the antioxidant status of the red blood cell (RBC) and is also used as an indicator of cell age |
| 18513544 | Therefore, the development of a simultaneous determination of G6PD activity (via the determination of nicotinamide adenine dinucleotide phosphate (NADPH)) in RBCs and the determination of deformation-induced RBC-derived ATP is described |
| 18513544 | The NADPH and ATP were determined while undergoing a chemically induced aging process via inhibition of G6PD with dehydroepiandroesterone (DHEA) |
| 18513544 | In order to demonstrate a direct relationship between G6PD activity and deformation-induced ATP release from RBCs, a simultaneous microflow determination of G6PD activity and ATP release was performed |
| 18513544 | In order to demonstrate a direct relationship between G6PD activity and deformation-induced ATP release from RBCs, a simultaneous microflow determination of G6PD activity and ATP release was performed |
| 14980702 | Glucose-6-phosphate dehydrogenase (G6PD) is involved in the generation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and the maintenance of cellular redox balance |
| 14980702 | Glucose-6-phosphate dehydrogenase (G6PD) is involved in the generation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and the maintenance of cellular redox balance |
| 14980702 | In the present study, we demonstrate abatement of both the intracellular G6PD activity and the ratio NADPH/NADP(+) during the serial passage of G6PD-deficient cells |
| 14980702 | Decreases in both the intracellular G6PD activity and the NADPH/NADP(+) ratio were concomitant with an increase in 8-OHdG level in H(2)O(2)-induced senescent cells |
| 14980702 | Exogenous expression of G6PD protected the deficient cells from stress-induced senescence |
| 11985579 | The 'Mediterranean' variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency is due to the C563CT point mutation, leading to replacement of Ser with Phe at position 188, resulting in acute haemolysis triggered by oxidants |
| 11985579 | The 'Mediterranean' variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency is due to the C563CT point mutation, leading to replacement of Ser with Phe at position 188, resulting in acute haemolysis triggered by oxidants |
| 11985579 | The aim of this work was to study the possible involvement of protein aspartate damage in the mechanism linking the G6PD defect and erythrocyte injury, through oxidative stress |
| 11985579 | Patients affected by G6PD deficiency (Mediterranean variant) were selected |
| 10980404 | Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts |
| 10980404 | Glucose-6-phosphate dehydrogenase (G6PD) is involved in the generation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and the maintenance of the cellular redox balance |
| 10980404 | Glucose-6-phosphate dehydrogenase (G6PD) is involved in the generation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and the maintenance of the cellular redox balance |
| 10980404 | The biological effects of G6PD deficiency in nucleated cells were studied using G6PD-deficient human foreskin fibroblasts (HFF) |
| 10980404 | The importance of G6PD activity in cell growth was corroborated by the finding that ectopic expression of active G6PD in the deficient cells prevented their growth retardation and early onset of senescence |
| 10980404 | The importance of G6PD activity in cell growth was corroborated by the finding that ectopic expression of active G6PD in the deficient cells prevented their growth retardation and early onset of senescence |
| 10980404 | Taken together, our results show that G6PD deficiency predisposes human fibroblasts to retarded growth and accelerated cellular senescence |
| 9343976 | Second, transgenic mice have been produced which express high levels of the human antioxidant enzymes, superoxide dismutase and glucose-6-phosphate dehydrogenase, in their erythrocytes |
| 8910257 | Pyruvate kinase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity significantly increased after treatment of confluent-phase cells with 10 nM 1,25(OH)2D3 for 24 h |
| 8910257 | Steroid specificity was established by the failure of 10 nM levels of 25-hydroxyvitamin D3 to affect the enzyme activities, while estradiol-17 beta and progesterone produced a slight increase in glucose-6-phosphate dehydrogenase and lactate dehydrogenase levels, respectively |
| 1764909 | The activities of six enzymes: glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD), hexokinase (Hx), glutamate oxaloacetate transminase (GOT), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE), were measured in the red cells of different ages which were obtained either by centrifugation or experimental anaemia |
| 1764909 | The activities of six enzymes: glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD), hexokinase (Hx), glutamate oxaloacetate transminase (GOT), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE), were measured in the red cells of different ages which were obtained either by centrifugation or experimental anaemia |
| 1756776 | Eight enzyme loci (G6PD, PGM1, PGM3, PepA, PGD, ADA, GLO1, and ME), proved to be informative in establishing unique allozyme genetic signatures for all of the cell strains established from the same species and from the same organ |
| 1666816 | These procedures have been used to monitor the decline of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activity during the process of red cell aging in normal subjects and in beta-thal carriers, to study transfused patients with G6PD and pyruvate kinase (PK) deficiency and to test the effects of inositol hexaphosphate (IHP) encapsulation on RBC subpopulations |
| 1666816 | These procedures have been used to monitor the decline of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activity during the process of red cell aging in normal subjects and in beta-thal carriers, to study transfused patients with G6PD and pyruvate kinase (PK) deficiency and to test the effects of inositol hexaphosphate (IHP) encapsulation on RBC subpopulations |
| 1666816 | These procedures have been used to monitor the decline of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activity during the process of red cell aging in normal subjects and in beta-thal carriers, to study transfused patients with G6PD and pyruvate kinase (PK) deficiency and to test the effects of inositol hexaphosphate (IHP) encapsulation on RBC subpopulations |
| 2085437 | Changes in band 3 structure that are the result of unstable hemoglobin or a deficiency in glucose-6-phosphate dehydrogenase and that do not affect anion transport have no effect on glucose transport characteristics |
| 3571220 | Moreover, treatment of glucose-6-phosphate dehydrogenase with a mixed function oxidation system leads to oxidative modification and increased heat lability of the enzyme |
| 3757268 | The enzyme activities of glucose-6-phosphate dehydrogenase (G6PD), 6-phospho-gluconate dehydrogenase (6PGD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were measured in normal human red cells separated centrifugally in a discontinuous density gradient of Percoll |
| 3757268 | The enzyme activities of glucose-6-phosphate dehydrogenase (G6PD), 6-phospho-gluconate dehydrogenase (6PGD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were measured in normal human red cells separated centrifugally in a discontinuous density gradient of Percoll |
| 3757268 | Activities of G6PD, GSH-Px and GR decreased with red cell aging |
| 4061449 | Characteristics of hexokinase, pyruvate kinase, and glucose-6-phosphate dehydrogenase during adult and neonatal reticulocyte maturation |
| 4061449 | 40, PK), and glucose-6-phosphate dehydrogenase (EC 1 |
| 4061449 | 49, G6PD) were studied during reticulocyte maturation and further red cell senescence |
| 4061449 | Analysis of the fraction with lowest density showed an almost linear and steep decline of HK, PK, and G6PD activity with a decreasing number of reticulocytes |
| 4061449 | These data are therefore illustrative for a biphasic activity decay pattern of HK, PK, and G6PD during both adult and neonatal red cell aging |
| 3012219 | Reduced glutathione (GSH), GSH stability and glucose-6-phosphate dehydrogenase (G6PD) activity in fractionated red cells decreased with age, while oxidized glutathione (GSSG) and methemoglobin (MetHb) increased with age |
| 3012219 | Reduced glutathione (GSH), GSH stability and glucose-6-phosphate dehydrogenase (G6PD) activity in fractionated red cells decreased with age, while oxidized glutathione (GSSG) and methemoglobin (MetHb) increased with age |
| 3972471 | Among other characteristics, the transformed KMST-6 cells exhibit a B-type isozyme pattern of glucose-6-phosphate dehydrogenase, lactate-dehydrogenase isozyme pattern of human origin, no evidence of viral infection and no production of C-type virus particles |
| 6712629 | The specific activities per cell were determined for glucose-6-phosphate dehydrogenase (EC 1 |
| 7132238 | The specific activities of glucose-6-phosphate dehydrogenase, catalase, glutathione peroxidase, glutathione reductases as well as the glutathione and selenium content were highest in the youngest cell and uniformly decreased by about 20-30% in the eldest group |
| 1251580 | On the other hand, a borderline reduction of PK activity was found, and the activity of G-6PD underwent a steady though unimpressive decrease to 70% of the physiological average |
| 1215835 | Red cell aging was associated with a decline in cell volume, haemoglobin, G6PD and ATP content |
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