HCSGD entry for FYN

1. General information

Official gene symbolFYN
Entrez ID2534
Gene full nameFYN oncogene related to SRC, FGR, YES
Other gene symbolsSLK SYN p59-FYN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0001948Glycoprotein bindingIEA IPImolecular_function
GO:0004713Protein tyrosine kinase activityEXP IEA TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0006816Calcium ion transportNASbiological_process
GO:0007166Cell surface receptor signaling pathwayIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007612LearningTASbiological_process
GO:0007631Feeding behaviorTASbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015631Tubulin bindingIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016032Viral processTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030900Forebrain developmentIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042177Negative regulation of protein catabolic processIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042608T cell receptor bindingIEAmolecular_function
GO:0042609CD4 receptor bindingIEAmolecular_function
GO:0042610CD8 receptor bindingIEAmolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0044325Ion channel bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046875Ephrin receptor bindingIPImolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050798Activated T cell proliferationIEAbiological_process
GO:0050852T cell receptor signaling pathwayIDAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0050966Detection of mechanical stimulus involved in sensory perception of painIEAbiological_process
GO:0051428Peptide hormone receptor bindingIEAmolecular_function
GO:0070851Growth factor receptor bindingIPImolecular_function
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
GO:1900182Positive regulation of protein localization to nucleusIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00608360240.92576380080.20581812341.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4425854601
GSE13712_SHEARUp0.1733021090
GSE13712_STATICDown-0.1488075120
GSE19018Up0.6118566659
GSE19899_A1Up0.0481777497
GSE19899_A2Up1.5757835884
PubMed_21979375_A1Up0.9149261322
PubMed_21979375_A2Up1.0974771576
GSE35957Up0.3008075013
GSE36640Up0.5917180669
GSE54402Down-0.3029238599
GSE9593Up0.1524655278
GSE43922Up0.1073469727
GSE24585Down-0.3032654662
GSE37065Up0.3433891517
GSE28863_A1Up0.7262903807
GSE28863_A2Up0.8874283316
GSE28863_A3Down-0.2551747468
GSE28863_A4Down-0.2293423117
GSE48662Up0.3912834531

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DasatinibDB01254 -
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-EthaneDB02078 EXPT02565

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT022048MicroarrayFunctional MTI (Weak)17612493
hsa-miR-93-3pMIMAT0004509MIRT038910CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.