HCSGD entry for RICTOR
1. General information
| Official gene symbol | RICTOR |
|---|---|
| Entrez ID | 253260 |
| Gene full name | RPTOR independent companion of MTOR, complex 2 |
| Other gene symbols | PIA mAVO3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001938 | Positive regulation of endothelial cell proliferation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009790 | Embryo development | IEA ISS | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0030838 | Positive regulation of actin filament polymerization | IEA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0031532 | Actin cytoskeleton reorganization | IMP | biological_process |
| GO:0031929 | TOR signaling | IEA | biological_process |
| GO:0031932 | TORC2 complex | IDA IEA | cellular_component |
| GO:0032008 | Positive regulation of TOR signaling | IMP | biological_process |
| GO:0032314 | Regulation of Rac GTPase activity | IEA | biological_process |
| GO:0032956 | Regulation of actin cytoskeleton organization | IEA IMP | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0043022 | Ribosome binding | IEA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0051896 | Regulation of protein kinase B signaling | IDA | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0665998936 | 0.3445032370 | 0.5559707580 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2057895685 |
| GSE13712_SHEAR | Up | 0.1079476473 |
| GSE13712_STATIC | Down | -0.1483408947 |
| GSE19018 | Up | 0.3865543902 |
| GSE19899_A1 | Up | 0.1641125142 |
| GSE19899_A2 | Down | -0.0313297201 |
| PubMed_21979375_A1 | Up | 0.0702410061 |
| PubMed_21979375_A2 | Up | 0.2383491774 |
| GSE35957 | Up | 0.1314930873 |
| GSE36640 | Down | -0.2178555125 |
| GSE54402 | Up | 0.3018650523 |
| GSE9593 | Up | 0.1842152114 |
| GSE43922 | Up | 0.3706264433 |
| GSE24585 | Up | 0.7901048465 |
| GSE37065 | Up | 0.5542462214 |
| GSE28863_A1 | Up | 0.0250550830 |
| GSE28863_A2 | Up | 0.5807415786 |
| GSE28863_A3 | Down | -0.8465596171 |
| GSE28863_A4 | Down | -0.5143298035 |
| GSE48662 | Down | -0.2932904383 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-218-5p | MIMAT0000275 | MIRT006105 | HITS-CLIP//Luciferase reporter assay//Western blot | Functional MTI | 23212916 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT006105 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018260 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020841 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT038935 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050668 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25484082 | Using human nonsenescent "young" and replicative senescent endothelial cells as well as Apolipoprotein E-deficient (apoe(-/-)Arg2(+/+)) and Arg2-deficient apoe(-/-) (apoe(-/-)arg2(-/-)) mice fed a high-fat diet for 10 wk as the atherosclerotic animal model, we show here that overexpression of ARG2 in the young cells suppresses endothelial autophagy with concomitant enhanced expression of RICTOR, the essential component of the MTORC2 complex, leading to activation of the AKT-MTORC1-RPS6KB1/S6K1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1) cascade and inhibition of PRKAA/AMPK (protein kinase, AMP-activated, alpha catalytic subunit) |
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