HCSGD entry for FUCA1


1. General information

Official gene symbolFUCA1
Entrez ID2517
Gene full namefucosidase, alpha-L- 1, tissue
Other gene symbolsFUCA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004560Alpha-L-fucosidase activityTASmolecular_function
GO:0005737CytoplasmICcellular_component
GO:0005764LysosomeIBAcellular_component
GO:0006004Fucose metabolic processIEAbiological_process
GO:0006027Glycosaminoglycan catabolic processNASbiological_process
GO:0042806Fucose bindingIBAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06916423010.05137321150.56286598700.4262345936

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5919020024
GSE13712_SHEARDown-0.4080219142
GSE13712_STATICUp0.0060948276
GSE19018Up0.3462455677
GSE19899_A1Down-0.1101721802
GSE19899_A2Up0.4235421110
PubMed_21979375_A1Down-0.9613340120
PubMed_21979375_A2Up0.3480250513
GSE35957Down-0.1027493238
GSE36640Up0.9306621176
GSE54402Down-0.8839835148
GSE9593Up0.5378848491
GSE43922Down-0.1826978168
GSE24585Up0.6082690333
GSE37065Up0.3416337403
GSE28863_A1Down-0.8898935716
GSE28863_A2Up1.0402607475
GSE28863_A3Down-0.7184733076
GSE28863_A4Down-0.4059843926
GSE48662Down-0.1453919681

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23759573Senescence-associated lysosomal alpha-L-fucosidase (SA-alpha-Fuc): a sensitive and more robust biomarker for cellular senescence beyond SA-beta-Gal
23673343Here, we identified alpha-L-fucosidase (alpha-Fuc) as a novel sensitive biomarker for cellular senescence
522513On the other hand, no change occurred in alpha-L-fucosidase, alpha-D-mannosidase, alpha-D-galactosidase and alpha-D-glucosidase activities
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