HCSGD entry for FTH1
1. General information
| Official gene symbol | FTH1 |
|---|---|
| Entrez ID | 2495 |
| Gene full name | ferritin, heavy polypeptide 1 |
| Other gene symbols | FHC FTH FTHL6 PIG15 PLIF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004322 | Ferroxidase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006826 | Iron ion transport | IEA | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | IEA TAS | biological_process |
| GO:0006880 | Intracellular sequestering of iron ion | IDA | biological_process |
| GO:0006892 | Post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0006955 | Immune response | ISS | biological_process |
| GO:0008043 | Intracellular ferritin complex | TAS | cellular_component |
| GO:0008199 | Ferric iron binding | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | ISS | biological_process |
| GO:0048147 | Negative regulation of fibroblast proliferation | IDA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1805195547 | 0.4203827172 | 0.8323582633 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4917370442 |
| GSE13712_SHEAR | Down | -0.2770673218 |
| GSE13712_STATIC | Down | -0.1704865597 |
| GSE19018 | Down | -0.1283887673 |
| GSE19899_A1 | Down | -0.3764444983 |
| GSE19899_A2 | Down | -0.0076851832 |
| PubMed_21979375_A1 | Down | -0.3849454848 |
| PubMed_21979375_A2 | Up | 0.0895311132 |
| GSE35957 | Up | 0.3185785565 |
| GSE36640 | Up | 0.6248546198 |
| GSE54402 | Down | -0.2094702160 |
| GSE9593 | Up | 0.7739553592 |
| GSE43922 | Down | -0.0946548413 |
| GSE24585 | Up | 0.1888416444 |
| GSE37065 | Up | 0.1995470495 |
| GSE28863_A1 | Up | 0.4254051914 |
| GSE28863_A2 | Up | 0.2108399452 |
| GSE28863_A3 | Up | 0.0394202704 |
| GSE28863_A4 | Down | -0.3518554376 |
| GSE48662 | Up | 0.1178717417 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Iron Dextran | DB00893 | APRD01053 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030032 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031951 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-941 | MIMAT0004984 | MIRT036560 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050899 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
