HCSGD entry for FRZB

1. General information

Official gene symbolFRZB
Entrez ID2487
Gene full namefrizzled-related protein
Other gene symbolsFRE FRITZ FRP-3 FRZB-1 FRZB-PEN FRZB1 FZRB OS1 SFRP3 SRFP3 hFIZ
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0001944Vasculature developmentIBAbiological_process
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0007409AxonogenesisIRDbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008406Gonad developmentIBAbiological_process
GO:0010721Negative regulation of cell developmentIEAbiological_process
GO:0014033Neural crest cell differentiationIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0017147Wnt-protein bindingIBA ISSmolecular_function
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0030178Negative regulation of Wnt signaling pathwayIDA ISSbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0032589Neuron projection membraneIKRcellular_component
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0043065Positive regulation of apoptotic processIGIbiological_process
GO:0045600Positive regulation of fat cell differentiationIDAbiological_process
GO:0060029Convergent extension involved in organogenesisIEAbiological_process
GO:0060056Mammary gland involutionIBAbiological_process
GO:0060429Epithelium developmentIBAbiological_process
GO:0061037Negative regulation of cartilage developmentIBAbiological_process
GO:0061053Somite developmentIEAbiological_process
GO:0070367Negative regulation of hepatocyte differentiationIBAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:0090103Cochlea morphogenesisIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80778864020.17253643860.99999024730.8042068520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1172915366
GSE13712_SHEARUp0.0224599608
GSE13712_STATICDown-0.0029655474
GSE19018Down-0.3107604609
GSE19899_A1Down-0.0233636813
GSE19899_A2Down-1.1059319541
PubMed_21979375_A1Down-0.5171472333
PubMed_21979375_A2Down-0.6595705641
GSE35957Down-0.0190983992
GSE36640Down-0.2925492070
GSE54402Down-0.1269232685
GSE9593Up0.3167373605
GSE43922Down-0.2001663977
GSE24585Up0.1083770075
GSE37065Up0.0935656251
GSE28863_A1Down-0.1218482341
GSE28863_A2Up0.0829011324
GSE28863_A3Up0.1444332453
GSE28863_A4Up0.0929377279
GSE48662Up0.7146183033

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30b-5pMIMAT0000420MIRT023431SequencingFunctional MTI (Weak)20371350
hsa-miR-744-5pMIMAT0004945MIRT037469CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22927647Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt signaling, is oversecreted upon cellular senescence caused by DNA damage or oxidative stress
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