HCSGD entry for MTOR
1. General information
| Official gene symbol | MTOR |
|---|---|
| Entrez ID | 2475 |
| Gene full name | mechanistic target of rapamycin (serine/threonine kinase) |
| Other gene symbols | FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0001030 | RNA polymerase III type 1 promoter DNA binding | IDA | molecular_function |
| GO:0001031 | RNA polymerase III type 2 promoter DNA binding | IDA | molecular_function |
| GO:0001032 | RNA polymerase III type 3 promoter DNA binding | IDA | molecular_function |
| GO:0001156 | TFIIIC-class transcription factor binding | IDA | molecular_function |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | IEA | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005942 | Phosphatidylinositol 3-kinase complex | NAS | cellular_component |
| GO:0005979 | Regulation of glycogen biosynthetic process | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA IMP | biological_process |
| GO:0006950 | Response to stress | IMP | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007281 | Germ cell development | IEA | biological_process |
| GO:0007584 | Response to nutrient | NAS | biological_process |
| GO:0008144 | Drug binding | IEA | molecular_function |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010507 | Negative regulation of autophagy | ISS | biological_process |
| GO:0010592 | Positive regulation of lamellipodium assembly | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IMP | biological_process |
| GO:0010831 | Positive regulation of myotube differentiation | IEA | biological_process |
| GO:0012505 | Endomembrane system | IDA | cellular_component |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016049 | Cell growth | IDA TAS | biological_process |
| GO:0016242 | Negative regulation of macroautophagy | IEA | biological_process |
| GO:0016301 | Kinase activity | IDA TAS | molecular_function |
| GO:0016310 | Phosphorylation | IDA | biological_process |
| GO:0016605 | PML body | IEA ISS | cellular_component |
| GO:0018105 | Peptidyl-serine phosphorylation | IEA IMP | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030163 | Protein catabolic process | TAS | biological_process |
| GO:0030838 | Positive regulation of actin filament polymerization | IEA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0031529 | Ruffle organization | IEA | biological_process |
| GO:0031669 | Cellular response to nutrient levels | IEA ISS | biological_process |
| GO:0031929 | TOR signaling | IMP | biological_process |
| GO:0031931 | TORC1 complex | IDA IEA IMP | cellular_component |
| GO:0031932 | TORC2 complex | IDA | cellular_component |
| GO:0031998 | Regulation of fatty acid beta-oxidation | IEA | biological_process |
| GO:0032095 | Regulation of response to food | IEA | biological_process |
| GO:0032314 | Regulation of Rac GTPase activity | IEA | biological_process |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0032956 | Regulation of actin cytoskeleton organization | IMP | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0040007 | Growth | NAS | biological_process |
| GO:0043022 | Ribosome binding | IEA | molecular_function |
| GO:0043200 | Response to amino acid | IDA IEA | biological_process |
| GO:0043610 | Regulation of carbohydrate utilization | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045727 | Positive regulation of translation | IDA IEA | biological_process |
| GO:0045792 | Negative regulation of cell size | IEA | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IEA | biological_process |
| GO:0045945 | Positive regulation of transcription from RNA polymerase III promoter | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA IEA | biological_process |
| GO:0046889 | Positive regulation of lipid biosynthetic process | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0051219 | Phosphoprotein binding | IPI | molecular_function |
| GO:0051496 | Positive regulation of stress fiber assembly | IEA | biological_process |
| GO:0051534 | Negative regulation of NFAT protein import into nucleus | IEA | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IEA | biological_process |
| GO:0070438 | MTOR-FKBP12-rapamycin complex | IEA | cellular_component |
| GO:0071456 | Cellular response to hypoxia | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1579162760 | 0.8976042969 | 0.7883731462 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0018615126 |
| GSE13712_SHEAR | Up | 0.0344173913 |
| GSE13712_STATIC | Up | 0.0125807810 |
| GSE19018 | Up | 0.1642120337 |
| GSE19899_A1 | Up | 0.0980259215 |
| GSE19899_A2 | Down | -0.1647308437 |
| PubMed_21979375_A1 | Up | 0.0420465407 |
| PubMed_21979375_A2 | Up | 0.3278819452 |
| GSE35957 | Down | -0.0317325853 |
| GSE36640 | Up | 0.0501946567 |
| GSE54402 | Up | 0.0039168666 |
| GSE9593 | Down | -0.1605626597 |
| GSE43922 | Up | 0.2566268489 |
| GSE24585 | Up | 0.2065494841 |
| GSE37065 | Down | -0.0112638520 |
| GSE28863_A1 | Up | 0.8319174239 |
| GSE28863_A2 | Up | 1.0529296279 |
| GSE28863_A3 | Down | -0.1395965432 |
| GSE28863_A4 | Down | -0.2488968139 |
| GSE48662 | Down | -0.0580801693 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pimecrolimus | DB00337 | APRD01182 |
| Sirolimus | DB00877 | APRD00178 | DB02439 |
| Everolimus | DB01590 | - |
| AP1903 | DB04974 | - |
| SF1126 | DB05210 | - |
| XL765 | DB05241 | - |
| Temsirolimus | DB06287 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-99b-5p | MIMAT0000689 | MIRT006564 | FACS//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22299047 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT006146 | FACS//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22299047 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT006146 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23292834 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT006146 | Reporter assay;Western blot | Functional MTI | 21383697 |
| hsa-miR-144-3p | MIMAT0000436 | MIRT006872 | Luciferase reporter assay | Functional MTI | 22983984 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT007365 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23292834 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031485 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037492 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047241 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26147250 | MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation |
| 26147250 | MTOR inhibition suppressed the secretion of inflammatory cytokines by senescent cells |
| 25484082 | ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis |
| 24036549 | Markers of cellular senescence depend in part on the MTOR (mechanistic target of rapamycin) pathway |
| 24036549 | MTOR participates in geroconversion, a conversion from reversible cell cycle arrest to irreversible senescence |
| 23989658 | Prolonged autophagy by MTOR inhibitor leads radioresistant cancer cells into senescence |
| 23989658 | Many reports suggest that inhibitors targeting the mechanistic target of rapamycin (MTOR) can sensitize cancer cells to the effect of radiation, although by which mechanism MTOR inhibitors enhance the efficacy of radiation toward cancer cells remains to be elucidated |
| 23989658 | Our studies indicate that a potent and persistent activation of autophagy via inhibition of the MTOR pathway, even in cancer cells where autophagy is occurring, can trigger premature senescence, cellular proliferation arrest |
| 23989658 | Combined treatment of MTOR inhibitor and radiation induce heterochromatin formation, an irreversible growth arrest and an increase of senescence-associated GLB1 (beta-galactosidase) activity, which appear to result from a constant activation of TP53 and a restoration in the activity of retinoblastoma 1 protein (RB1)-E2F1 |
| 23989658 | Thus, this study provides evidence that promoting cellular senescence via inhibition of the MTOR pathway may serve as an avenue to augment radiosensitivity in cancer cells that initiate an autophagy-survival mode to radiotherapy |
| 23852369 | When the cell cycle becomes arrested, MTOR (mechanistic Target of Rapamycin) converts reversible arrest into senescence (geroconversion) |
| 23852369 | We also used MEL10 cells in which MEK inhibitors do not inhibit MTOR |
| 23852369 | Elimination of cyclin D1 by siRNA did not prevent other markers of senescence that are consistent with the lack of its effect on MTOR |
| 23852369 | Our data confirmed that a mere inhibition of the cell cycle was sufficient to cause senescence, providing MTOR was active, and inhibition of MEK partially inhibited MTOR in a cell-type-dependent manner |
| 23852369 | Third, inhibition of MEK was sufficient to eliminate cyclin D1, regardless of MTOR |
| 23192222 | Hypoxia, MTOR and autophagy: converging on senescence or quiescence |
| 23192222 | Also, can inhibition of MTOR and stimulation of autophagy explain the gerosuppressive effects of hypoxia |
| 23151465 | Evidence is emerging that CR decelerates aging by deactivating MTOR (Target of Rapamycin) |
| 20876940 | TP53 and MTOR crosstalk to regulate cellular senescence |
| 20876940 | Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53 |
| 18075305 | Rapamycin (a specific Mtor inhibitor) could lead to G(1) arrest of many malignant cell lines, and currently analogs of rapamycin are being investigated as a cancer chemotherapeutic adjuvant |
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