HCSGD entry for RNASEH1
1. General information
| Official gene symbol | RNASEH1 |
|---|---|
| Entrez ID | 246243 |
| Gene full name | ribonuclease H1 |
| Other gene symbols | H1RNA RNH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | TAS | molecular_function |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0004523 | RNA-DNA hybrid ribonuclease activity | IEA | molecular_function |
| GO:0004540 | Ribonuclease activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006264 | Mitochondrial DNA replication | IEA | biological_process |
| GO:0006401 | RNA catabolic process | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5092629117 | 0.0158360359 | 0.9999902473 | 0.2460568477 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6119749804 |
| GSE13712_SHEAR | Up | 0.0686895609 |
| GSE13712_STATIC | Up | 0.0255327586 |
| GSE19018 | Down | -0.8119063200 |
| GSE19899_A1 | Down | -0.5883659983 |
| GSE19899_A2 | Down | -0.3800345841 |
| PubMed_21979375_A1 | Up | 0.0116059454 |
| PubMed_21979375_A2 | Down | -0.5727247608 |
| GSE35957 | Up | 0.2412189123 |
| GSE36640 | Down | -0.1718677725 |
| GSE54402 | Up | 0.2155488241 |
| GSE9593 | Up | 0.2129681820 |
| GSE43922 | Down | -0.3559426167 |
| GSE24585 | Down | -0.7339800184 |
| GSE37065 | Down | -0.1460220790 |
| GSE28863_A1 | Up | 0.6813094201 |
| GSE28863_A2 | Up | 0.0774967329 |
| GSE28863_A3 | Up | 0.0802026270 |
| GSE28863_A4 | Down | -0.8392420733 |
| GSE48662 | Down | -0.4428382626 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029640 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT042080 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043509 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045143 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
