HCSGD entry for CNOT6L
1. General information
| Official gene symbol | CNOT6L |
|---|---|
| Entrez ID | 246175 |
| Gene full name | CCR4-NOT transcription complex, subunit 6-like |
| Other gene symbols | CCR4b |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IEA TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0004535 | Poly(A)-specific ribonuclease activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA IMP | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010606 | Positive regulation of cytoplasmic mRNA processing body assembly | IMP | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030014 | CCR4-NOT complex | IDA | cellular_component |
| GO:0031047 | Gene silencing by RNA | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0061157 | MRNA destabilization | IEA | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8765493902 | 0.1283311842 | 0.9999902473 | 0.6901421074 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0075442915 |
| GSE13712_SHEAR | Up | 0.0927837402 |
| GSE13712_STATIC | Down | -0.0553752338 |
| GSE19018 | Up | 0.1467068673 |
| GSE19899_A1 | Up | 0.0032379642 |
| GSE19899_A2 | Down | -0.2297400980 |
| PubMed_21979375_A1 | Down | -0.5509752697 |
| PubMed_21979375_A2 | Down | -0.1810085707 |
| GSE35957 | Down | -0.1505635655 |
| GSE36640 | Down | -0.5314329175 |
| GSE54402 | Down | -0.1482459951 |
| GSE9593 | Down | -0.0961902260 |
| GSE43922 | Down | -0.0697005983 |
| GSE24585 | Up | 0.0306326716 |
| GSE37065 | Up | 0.0882385101 |
| GSE28863_A1 | Up | 0.4142752244 |
| GSE28863_A2 | Up | 0.5109072787 |
| GSE28863_A3 | Down | -0.9195138538 |
| GSE28863_A4 | Down | -0.1412978204 |
| GSE48662 | Down | -0.1635827891 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044340 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045252 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
