HCSGD entry for ALOX12B

1. General information

Official gene symbolALOX12B
Entrez ID242
Gene full namearachidonate 12-lipoxygenase, 12R type
Other gene symbols12R-LOX ARCI2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004052Arachidonate 12-lipoxygenase activityIMP TASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0006497Protein lipidationISSbiological_process
GO:0006665Sphingolipid metabolic processIDAbiological_process
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0016702Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIDAmolecular_function
GO:0019369Arachidonic acid metabolic processIMP ISS TASbiological_process
GO:0019372Lipoxygenase pathwayIDA IMP TASbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0043651Linoleic acid metabolic processISSbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046513Ceramide biosynthetic processISSbiological_process
GO:0051122Hepoxilin biosynthetic processISSbiological_process
GO:0055114Oxidation-reduction processIDA IMPbiological_process
GO:0061436Establishment of skin barrierISSbiological_process
GO:0070257Positive regulation of mucus secretionIMPbiological_process
GO:1990136Linoleate 9S-lipoxygenase activityISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52716535090.90294211090.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0135989612
GSE13712_SHEARDown-0.1246374423
GSE13712_STATICDown-0.1476389214
GSE19018Up0.0957431039
GSE19899_A1Down-0.0309978782
GSE19899_A2Down-0.0922860543
PubMed_21979375_A1Up0.0952949273
PubMed_21979375_A2Down-0.0143825150
GSE35957Up0.1195879976
GSE36640Up0.0532016364
GSE54402Up0.2173163376
GSE9593Up0.0526002170
GSE43922Up0.0288528170
GSE24585Up0.0638503098
GSE37065Down-0.0545286859
GSE28863_A1Up0.1136129063
GSE28863_A2Up0.0282435460
GSE28863_A3Up0.3484195433
GSE28863_A4Up0.1139724412
GSE48662Up0.0990714181

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.