HCSGD entry for PRPF6
1. General information
| Official gene symbol | PRPF6 |
|---|---|
| Entrez ID | 24148 |
| Gene full name | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) |
| Other gene symbols | ANT-1 ANT1 C20orf14 Prp6 TOM U5-102K hPrp6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000244 | Spliceosomal tri-snRNP complex assembly | IC IMP | biological_process |
| GO:0000245 | Spliceosomal complex assembly | NAS | biological_process |
| GO:0000375 | RNA splicing, via transesterification reactions | NAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003713 | Transcription coactivator activity | IGI | molecular_function |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | NAS | cellular_component |
| GO:0005682 | U5 snRNP | IDA | cellular_component |
| GO:0006403 | RNA localization | IMP | biological_process |
| GO:0008380 | RNA splicing | NAS TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0043021 | Ribonucleoprotein complex binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046540 | U4/U6 x U5 tri-snRNP complex | IDA | cellular_component |
| GO:0050681 | Androgen receptor binding | IPI | molecular_function |
| GO:0071001 | U4/U6 snRNP | IDA | cellular_component |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0863886858 | 0.9680504388 | 0.6167294820 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1118849666 |
| GSE13712_SHEAR | Up | 0.1096503989 |
| GSE13712_STATIC | Down | -0.0110725645 |
| GSE19018 | Down | -0.0028970750 |
| GSE19899_A1 | Down | -0.0695963307 |
| GSE19899_A2 | Up | 0.4153284383 |
| PubMed_21979375_A1 | Up | 0.6248024953 |
| PubMed_21979375_A2 | Up | 0.0070633965 |
| GSE35957 | Up | 0.3024612448 |
| GSE36640 | Up | 0.0610795879 |
| GSE54402 | Up | 0.1075304402 |
| GSE9593 | Up | 0.0720645067 |
| GSE43922 | Up | 0.1563100572 |
| GSE24585 | Up | 0.0046234201 |
| GSE37065 | Down | -0.0512620307 |
| GSE28863_A1 | Up | 0.6376015685 |
| GSE28863_A2 | Up | 0.2898867718 |
| GSE28863_A3 | Down | -0.0050162352 |
| GSE28863_A4 | Up | 0.1184387105 |
| GSE48662 | Up | 0.1272072596 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036513 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045630 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046285 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
